Observational studyScientific reports2021
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01947621 (International Multicenter Registry on Takotsubo Cardiomyopathy), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
International Multicenter Registry on Takotsubo Cardiomyopathy
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- New insights into takotsubo syndrome: results from a multicenter cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Severe Biventricular Takotsubo Syndrome Triggered by Status Epilepticus With Pulmonary Embolism and Critical Illness Myopathy.JACC. Case reports · 2026Article
- Neurogenic shock to the heart: a rare case of meningitis-triggered reverse takotsubo cardiomyopathy.Proceedings (Baylor University. Medical Center) · 2026Article
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Takotsubo Cardiomyopathy: An Exploration of the Intersection Between Stress, Coronary Dysfunction, and Cardiac Outcomes.Reviews in cardiovascular medicine · 2025Review
- Takotsubo syndrome: Unraveling the mystery behind its triggers (Review).International journal of molecular medicine · 2025Review
- Neurological complications in Takotsubo syndrome: A case of concurrent acute stroke.Global cardiology science & practice · 2025Article
- Heart-Brain axis: is microvascular dysfunction the link between stroke and Takotsubo syndrome?The international journal of cardiovascular imaging · 2025Review
- When Is the Broken Heart Most Dangerous? Assessing Risk Factors to Predict Inpatient Death in Takotsubo Cardiomyopathy: Analysis of the National Inpatient Sample for 2021.Journal of the American Heart Association · 2025Article
- The Heart-Brain Axis: Key Concepts in Neurocardiology.Cardiology discovery · 2025Review
- Clinical applications of artificial intelligence and machine learning in neurocardiology: a comprehensive review.Frontiers in cardiovascular medicine · 2025Review
- Effects of cardiovascular risk factors and pre-existing diseases on the short-term outcome of Takotsubo syndrome.Wiener klinische Wochenschrift · 2024Article
- Unusual presentation of benzodiazepine withdrawal with Takotsubo syndrome: a case report.European heart journal. Case reports · 2024Article
- Neurological Disorders in Takotsubo Syndrome: Clinical Phenotypes and Outcomes.Journal of the American Heart Association · 2024Article
- Editorial: Cardiogenic shock: basic and clinical consideration, volume II.Frontiers in cardiovascular medicine · 2024Article
- Takotsubo syndrome: unravelling the enigma of the broken heart syndrome?-a narrative review.Cardiovascular diagnosis and therapy · 2023Review
- Triggers, characteristics, and hospital outcome of patients with Takotsubo syndrome: 10 years experience in a large university hospital centre.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- A contemporary update on cancer and takotsubo syndrome.Frontiers in cardiovascular medicine · 2023Review
- Stroke-Heart Syndrome: Recent Advances and Challenges.Journal of the American Heart Association · 2022Review
- Limbic Responses to Aversive Visual Stimuli during the Acute and Recovery Phase of Takotsubo Syndrome.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
12 authors at 20 institutions in 17 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights regarding neurological disease entities triggering TTS and to investigate the clinical profile and outcomes of TTS patients after primary neurological disorders. The International Takotsubo Registry is an observational multicenter collaborative effort of 45 centers in 14 countries (ClinicalTrials.gov, identifier NCT01947621). All patients in the registry fulfilled International Takotsubo Diagnostic Criteria. For the present study, patients were included if complete information on acute neurological disorders were available. 2402 patients in whom complete information on acute neurological status were available were analyzed. In 161 patients (6.7%) an acute neurological disorder was identified as the preceding triggering factor. The most common neurological disorders were seizures, intracranial hemorrhage, and ischemic stroke. Time from neurological symptoms to TTS diagnosis was ≤ 2 days in 87.3% of cases. TTS patients with neurological disorders were younger, had a lower female predominance, fewer cardiac symptoms, lower left ventricular ejection fraction, and higher levels of cardiac biomarkers. TTS patients with neurological disorders had a 3.2-fold increased odds of in-hospital mortality compared to TTS patients without neurological disorders. In this large-scale study, 1 out of 15 TTS patients had an acute neurological condition as the underlying triggering factor. Our data emphasize that a wide spectrum of neurological diseases ranging from benign to life-threatening encompass TTS. The high rates of adverse events highlight the need for clinical awareness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.