ArticleScientific reports2021
Ketogenic Diet as a potential treatment for traumatic brain injury in mice.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Administration of ketogenic intervention as a potential treatment during post-traumatic brain injury recovery: a scoping review.Frontiers in nutrition · 2026Review
- Sex differences in neuropathological response to traumatic brain injury: increased neuronal loss and astrogliosis in females.Brain structure & function · 2025Article
- Traumatic Brain Injury and Gut Microbiome: The Role of the Gut-Brain Axis in Neurodegenerative Processes.Current neurology and neuroscience reports · 2025Review
- Mitochondria: the hidden engines of traumatic brain injury-driven neurodegeneration.Frontiers in cellular neuroscience · 2025Review
- The evolving pathophysiology of TBI and the advantages of temporally-guided combination therapies.Neurochemistry international · 2024Review
- The Uncoupling Effect of 17β-Estradiol Underlies the Resilience of Female-Derived Mitochondria to Damage after Experimental TBI.Life (Basel, Switzerland) · 2024Article
- New insights into metabolism dysregulation after TBI.Journal of neuroinflammation · 2024Review
- Non-pharmacological interventions for traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Ketogenic diet and behavior: insights from experimental studies.Frontiers in nutrition · 2024Review
- Metabolic Messengers: ketone bodies.Nature metabolism · 2023Review
- Cognitive and Cellular Effects of Combined Organophosphate Toxicity and Mild Traumatic Brain Injury.Biomedicines · 2023Article
- Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer's disease.Frontiers in neuroscience · 2023Review
- Measuring anxiety-like behavior in a mouse model of mTBI: Assessment in standard and home cage assays.Frontiers in behavioral neuroscience · 2023Article
- Review
- Sirtuins functions in central nervous system cells under neurological disorders.Frontiers in physiology · 2022Review
- Exogenous Ketones and Lactate as a Potential Therapeutic Intervention for Brain Injury and Neurodegenerative Conditions.Frontiers in human neuroscience · 2022Review
- The Neuroimmune Nexus: Diet-Induced Obesity, Inflammation, and Diet-Modulated Recovery Following Traumatic Brain Injury.Neurotrauma reportsReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is a brain dysfunction without present treatment. Previous studies have shown that animals fed ketogenic diet (KD) perform better in learning tasks than those fed standard diet (SD) following brain injury. The goal of this study was to examine whether KD is a neuroprotective in TBI mouse model. We utilized a closed head injury model to induce TBI in mice, followed by up to 30 days of KD/SD. Elevated levels of ketone bodies were confirmed in the blood following KD. Cognitive and behavioral performance was assessed post injury and molecular and cellular changes were assessed within the temporal cortex and hippocampus. Y-maze and Novel Object Recognition tasks indicated that mTBI mice maintained on KD displayed better cognitive abilities than mTBI mice maintained on SD. Mice maintained on SD post-injury demonstrated SIRT1 reduction when compared with uninjured and KD groups. In addition, KD management attenuated mTBI-induced astrocyte reactivity in the dentate gyrus and decreased degeneration of neurons in the dentate gyrus and in the cortex. These results support accumulating evidence that KD may be an effective approach to increase the brain's resistance to damage and suggest a potential new therapeutic strategy for treating TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.