Evidence map›Paper›PMID 34876594›Full record

ArticleScientific reports2021

Distinct characteristics of multisystem inflammatory syndrome in children in Poland.

Kamila Maria Ludwikowska, Magdalena Okarska-Napierała, Natalia Dudek, Paweł Tracewski, Jacek Kusa, Krzysztof Piotr Piwoński, Aneta Afelt, Dominik Cysewski, Mateusz Biela, Bożena Werner and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  7. Treatment of multisystem inflammatory syndrome in children.World journal of pediatrics : WJP · 2024
    Review
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  14. Updates on Coronavirus Disease 2019 in Children in Japan.The Pediatric infectious disease journal · 2022
    Review
  15. Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 17 institutions in 3 countries.

Kamila Maria Ludwikowska *Department of Pediatric Infectious Diseases, Wroclaw Medical University, Chałubińskiego 2-2a, 50-368, Wrocław, Poland.
Magdalena Okarska-Napierała *Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Żwirki i Wigury 61, 02-091, Warsaw, Poland.
Natalia Dudek *Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Żwirki i Wigury 61, 02-091, Warsaw, Poland.
Paweł TracewskiDepartment of Pediatric Cardiology, Research and Development Center0, Regional Specialist Hospital in Wroclaw, Kamieńskiego 73a, 51-124, Wrocław, Poland.
Jacek KusaDepartment of Pediatric Cardiology, Research and Development Center0, Regional Specialist Hospital in Wroclaw, Kamieńskiego 73a, 51-124, Wrocław, Poland.
Krzysztof Piotr PiwońskiInterdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Pawinskiego 5A, 02-106, Warsaw, Poland.
Aneta AfeltInterdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Pawinskiego 5A, 02-106, Warsaw, Poland.
Dominik CysewskiInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106, Warsaw, Poland.
Mateusz BielaDepartment of Paediatrics and Rare Disorders, Wroclaw Medical University, Wrocław, Poland.
Bożena WernerDepartment of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Żwirki i Wigury 61, 02-091, Warsaw, Poland.
Teresa JackowskaDepartment of Pediatrics, The Medical Centre of Postgraduate Education, Cegłowska 80, 01-809, Warsaw, Poland.
Catherine Suski-GrabowskiInterdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Pawinskiego 5A, 02-106, Warsaw, Poland.
Miron Bartosz KursaInterdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Pawinskiego 5A, 02-106, Warsaw, Poland. M.Kursa@icm.edu.pl.
Ernest Kuchar *Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Żwirki i Wigury 61, 02-091, Warsaw, Poland.
Leszek Szenborn *Department of Pediatric Infectious Diseases, Wroclaw Medical University, Chałubińskiego 2-2a, 50-368, Wrocław, Poland.
MOIS CoR Study Group
Poznan University of Medical Sciences · PLWroclaw Medical University · PLMedical University of Warsaw · PLJan Kochanowski University · PLMedical University of Silesia · PLChildren's Memorial Health Institute · PLUniversity of Warsaw · PLŁukasiewicz Research Network – PORT Polish Center for Technology Development · PLMedical University of Białystok · PLCentral Clinical Hospital · PLFoundation of Cardiac Surgery Development · PLGrochowski Hospital · PLInstitut de Recherche pour le Développement · FRInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PLPolish Mother’s Memorial Hospital Research Institute · PLSilesian Center for Heart Disease · PLUniversity Hospital Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the winter months of 2020/2021 a wave of multisystem inflammatory syndrome in children (MIS-C) emerged in Poland. We present the results of a nationwide register aiming to capture and characterise MIS-C with a focus on severity determinants. The first MIS-C wave in Poland was notably high, hence our analysis involved 274 children. The group was 62.8% boys, with a median age of 8.8 years. Besides one Asian, all were White. Overall, the disease course was not as severe as in previous reports, however. Pediatric intensive care treatment was required for merely 23 (8.4%) of children, who were older and exhibited a distinguished clinical picture at hospital admission. We have also identified sex-dependent differences; teenage boys more often had cardiac involvement (decreased ejection fraction in 25.9% vs. 14.7%) and fulfilled macrophage activation syndrome definition (31.0% vs. 15.2%). Among all boys, those hospitalized in pediatric intensive care unit were significantly older (median 11.2 vs. 9.1 years). Henceforth, while ethnicity and sex may affect MIS-C phenotype, management protocols might be not universally applicable, and should rather be adjusted to the specific population.

Indexed as

AdolescentAge FactorsChildChild, PreschoolCohort StudiesCOVID-19Epidemiological MonitoringFemaleHumansIncidenceInfantIntensive Care Units, PediatricMaleMucocutaneous Lymph Node SyndromePolandPrevalence

Identifiers

PMID34876594
PMCPMC8651720
OpenAlexW4200361524

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.