Evidence map›Paper›PMID 34876574›Full record

ArticleNature communications2021

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages.

Yuxian Guo, Yaru Liu, Shihao Zhao, Wangting Xu, Yiqing Li, Pengwei Zhao, Di Wang, Hongqiang Cheng, Yuehai Ke, Xue Zhang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  12. Post‑translational modifications in diabetic kidney disease (Review).International journal of molecular medicine · 2026
    Review
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  15. Article
  16. Review
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  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuxian Guo *Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.
Yaru Liu *Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.
Shihao ZhaoDepartment of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.
Wangting XuDepartment of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.
Yiqing LiDepartment of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.
Pengwei ZhaoDepartment of Biochemistry, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.
Di WangInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.ORCID http://orcid.org/0000-0002-2712-1705
Hongqiang ChengDepartment of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China.ORCID http://orcid.org/0000-0001-9662-1570
Yuehai KeDepartment of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China. yke@zju.edu.cn.ORCID http://orcid.org/0000-0003-4146-1156
Xue ZhangDepartment of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, P.R. China. zhangxue@zju.edu.cn.ORCID http://orcid.org/0000-0001-5785-8217
Sir Run Run Shaw Hospital · CNZhejiang University · CNZhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress contributes to the pathogenesis of acute lung injury. Protein S-glutathionylation plays an important role in cellular antioxidant defense. Here we report that the expression of deglutathionylation enzyme Grx1 is decreased in the lungs of acute lung injury mice. The acute lung injury induced by hyperoxia or LPS is significantly relieved in Grx1 KO and Grx1

Indexed as

InflammationOxidative StressAcute Lung InjuryAnimalsFatty Acid-Binding ProteinsGene Expression RegulationGlutaredoxinsHyperoxiaLungMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutNeoplasm ProteinsOxidation-ReductionFabp5 protein, mouseFatty Acid-Binding ProteinsGlrx protein, mouseGlutaredoxinsNeoplasm ProteinsProtective AgentsRecombinant Proteins

Identifiers

PMID34876574
PMCPMC8651733
OpenAlexW4200000187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.