Evidence map›Paper›PMID 34876566›Full record

Trial reportBlood cancer journal2021

Ixazomib-based induction regimens plus ixazomib maintenance in transplant-ineligible, newly diagnosed multiple myeloma: the phase II, multi-arm, randomized UNITO-EMN10 trial.

Roberto Mina, Antonietta Pia Falcone, Sara Bringhen, Anna Marina Liberati, Norbert Pescosta, Maria Teresa Petrucci, Giovannino Ciccone, Andrea Capra, Francesca Patriarca, Delia Rota-Scalabrini and 18 more

Abstract readClinical Trial, Phase IILetterMulticenter Study
In one paragraph

Trial report in Blood cancer journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Roberto MinaSSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy. roberto.mina@unito.it.ORCID 0000-0002-8144-541X
Antonietta Pia FalconeHematology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Sara BringhenSSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.ORCID 0000-0003-4539-6363
Anna Marina LiberatiUniversità degli Studi di Perugia - A.O. Santa Maria di Terni, Terni, Italy.ORCID 0000-0002-3686-3188
Norbert PescostaReparto di Ematologia e Centro Trapianto Midollo Osseo, Ospedale Centrale, Bolzano, Italy.
Maria Teresa PetrucciHematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Giovannino CicconeUnit of Clinical Epidemiology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino and CPO Piemonte, Torino, Italy.
Andrea CapraSSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
Francesca PatriarcaHematology Division, DAME, University of Udine, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Delia Rota-ScalabriniMultidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO - IRCCS, Torino, Italy.
Francesca BonelloSSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.
Caterina MusolinoDivision of Hematology, University of Messina, Azienda Ospedaliera-Universitaria G. Martino, Messina, Italy.
Michele CeaClinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa and IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0003-3345-0799
Renato ZambelloDepartment of Medicine (DIMED), Hematology and Clinical Immunology Section, Padova; University School of Medicine, Padova, Italy.ORCID 0000-0002-8799-5324
Paola TacchettiIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Angelo BelottiDepartment of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy.ORCID 0000-0002-0617-3127
Claudia CelliniU.O. Ematologia, Ospedale Santa Maria delle Croci, Ravenna, Italy.
Laura ParisDivision of Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy.ORCID 0000-0002-8248-2343
Mariella GrassoAzienda Ospedaliera Santa Croce - Carle, Cuneo, Italy.
Sara AquinoU.O. Ematologia, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Lorenzo De PaoliEmatologia, Università del Piemonte Orientale, Novara, Italy.
Giovanni De SabbataEmatologia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Stelvio BallantiDivisione di Ematologia con Trapianto, Azienda Ospedaliera Santa Maria della Misericordia di Perugia, Perugia, Italy.
Massimo OffidaniClinica di Ematologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi di Ancona, Ancona, Italy.
Mario BoccadoroSSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.ORCID 0000-0001-8130-5209
Federico MonacoSC Ematologia, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID 0000-0002-4630-753X
Paolo CorradiniHematology and Bone Marrow Transplant Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan; University of Milan, Milan, Italy.ORCID 0000-0002-9186-1353
Alessandra LaroccaSSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.ORCID 0000-0002-2070-3702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAged, 80 and overAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBoron CompoundsFemaleGlycineHumansInduction ChemotherapyMaintenance ChemotherapyMaleMiddle AgedMultiple MyelomaTreatment OutcomeAntineoplastic AgentsBoron CompoundsGlycineixazomib

Identifiers

PMID34876566
PMCPMC8651653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.