Evidence map›Paper›PMID 34876471›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Taste Bud Connectome: Implications for Taste Information Processing.

Courtney E Wilson, Robert S Lasher, Ruibiao Yang, Yannick Dzowo, John C Kinnamon, Thomas E Finger

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Taste dysfunction in Long COVID.bioRxiv : the preprint server for biology · 2025
    Article
  6. A deadly taste: linking bitter taste receptors and apoptosis.Apoptosis : an international journal on programmed cell death · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Contribution of TRPC3-mediated CaPflugers Archiv : European journal of physiology · 2023
    Article
  18. Taste arbor structural variability analyzed across taste regions.The Journal of comparative neurology · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Courtney E WilsonRocky Mountain Taste and Smell Center, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado 80045.
Robert S LasherRocky Mountain Taste and Smell Center, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado 80045.
Ruibiao YangRocky Mountain Taste and Smell Center, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado 80045.
Yannick DzowoRocky Mountain Taste and Smell Center, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado 80045.
John C KinnamonRocky Mountain Taste and Smell Center, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado 80045.
Thomas E FingerRocky Mountain Taste and Smell Center, University of Colorado School of Medicine, CU Anschutz Medical Campus, Aurora, Colorado 80045 tom.finger@cuanschutz.edu.ORCID 0000-0001-5923-5099
Rocky Mountain MS Center · US

Funding

Purinergic signaling in taste budsR01DC012555 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI KINNAMON, SUE C. · 2012 to 2021
$3.9M
Illuminating the structure and function of Type I taste cellsR01DC017679 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI KINNAMON, SUE C. · 2019 to 2023
$2.5M
Scanning Blockface EM of Murine and Human Taste BudsR01DC014728 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI FINGER, THOMAS E · 2015 to 2020
$1.9M
Scanning Blockface 3D EM of taste buds: a new window into functional organizationR21DC013186 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI FINGER, THOMAS E · 2013 to 2014
$431k
NIDCD NIH HHS R01 DC012555NIDCD NIH HHS R01 DC014728NIDCD NIH HHS R01 DC017679NIDCD NIH HHS R21 DC013186
6 · The paper itself

Abstract

Taste buds contain multiple cell types, two of which mediate transduction of specific taste qualities: Type III cells transduce sour while Type II cells transduce either sweet, or bitter or umami. In order to discern the degree of interaction between different cell types and specificity of connectivity with the afferent nerve fibers (NFs), we employed serial blockface scanning electron microscopy (sbfSEM) through five circumvallate mouse taste buds. Points of contact between Type II and Type III cells are rare and lack morphologically identifiable synapses, suggesting that interaction between these cell types does not occur via synapses. Of the 127 NFs that make synaptic contacts with taste cells in the sampling volume, ∼70% (

Indexed as

AnimalsCell CommunicationConnectomeFemaleMaleMiceNerve NetSynapsesTasteTaste BudsCALHM1electron microscopylabeled linenerve fiberssynapsetaste buds

Identifiers

PMID34876471
PMCPMC8808728
OpenAlexW4200343912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.