Evidence map›Paper›PMID 34876469›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D

Gemma Navarro, William Rea, César Quiroz, Estefanía Moreno, Devan Gomez, Cody J Wenthur, Vicent Casadó, Lorenzo Leggio, Matthew C Hearing, Sergi Ferré

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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  13. Glucocorticoids, stress and eating: The mediating role of appetite-regulating hormones.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Review
  14. Article
  15. Review
  16. The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Gemma NavarroDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, 08028, Spain.
William ReaIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224.
César QuirozIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224.
Estefanía MorenoDepartment of Biochemistry and Molecular Biomedicine and Institute of Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.
Devan GomezDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin 53233.
Cody J WenthurSchool of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705.
Vicent CasadóDepartment of Biochemistry and Molecular Biomedicine and Institute of Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.
Lorenzo LeggioClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program, and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, Maryland 21224.
Matthew C HearingDepartment of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin 53233.ORCID 0000-0002-1691-219X
Sergi FerréIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224 sferre@intra.nida.nih.gov.
National Institutes of Health · USInstitute for Research in Biomedicine · ESMarquette University · USNational Institute on Drug Abuse · USUniversitat de Barcelona · ESUniversity of Wisconsin–Madison · US

Funding

Neurotransmitter Receptor Heteromers in the Striatal Spine ModuleZIADA000493 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI FERRE, SERGI · 2009 to 2025
$35.6M
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIADA000635 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LEGGIO, LORENZO · 2020 to 2025
$15.2M
6 · The paper itself

Abstract

Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a complex modulatory role that depends on its relative expression. D

Indexed as

AnimalsDopaminergic NeuronsGhrelinHumansMaleRatsRats, Sprague-DawleyRats, WistarReceptors, Dopamine D1Receptors, GhrelinVentral Tegmental AreaGhrelinReceptors, Dopamine D1Receptors, Ghrelindopaminedopaminergic neuronsghrelinmicrodialysisreceptor heteromersventral tegmental area

Identifiers

PMID34876469
PMCPMC8824505
OpenAlexW4200307297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.