ArticleBMJ health & care informatics2021
Association between the chronology of gestation and the morphometrical skin characteristics at childbirth: a development of predictive model.
Article in BMJ health & care informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Premature Infants With Pulmonary Complications Exhibit Decreased Skin Maturity Early After Birth: A Cross-Sectional Study.Pediatric pulmonology · 2026Article
- Highly Self-Adhesive and Biodegradable Silk Bioelectronics for All-In-One Imperceptible Long-Term Electrophysiological Biosignals Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Necrotizing Enterocolitis Detection in Premature Infants Using Broadband Optical Spectroscopy.Journal of biophotonics · 2025Article
- Gestational age assessed by optical skin reflection in low-birth-weight newborns: Applications in classification at birth.Frontiers in pediatrics · 2023Article
- Respiratory distress syndrome prediction at birth by optical skin maturity assessment and machine learning models for limited-resource settings: a development and validation study.Frontiers in pediatrics · 2023Article
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4 authors.
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Abstract
objectiveThe structural maturation of the skin is considered a potential marker of pregnancy dating. This study investigated the correlation between the morphometrical skin characteristics with the pregnancy chronology to propose models for predicting gestational age.
methodsA cross-sectional analysis selected 35 corpses of newborns. The biopsy was performed up to 48 hours after death in the periumbilical abdomen, palm and sole regions. Pregnancy chronology was based on the obstetric ultrasound before 14 weeks. The dimensions of the skin layers, area of glands and connective fibrous tissue were measured with imaging software support. Univariate and multivariate regression models on morphometric values were used to predict gestational age.
resultsGestational age at birth ranged from 20.3 to 41.2 weeks. Seventy-one skin specimens resulted in the analysis of 1183 digital histological images. The correlation between skin thickness and gestational age was positive and strong in both regions of the body. The highest univariate correlation between gestational age and skin thickness was using the epidermal layer dimensions, in palm (r=0.867, p<0.001). The multivariate modelling with the thickness of the abdominal epidermis, the dermis and the area of the sebaceous glands adjusted had the highest correlation with gestational age (r=0.99, p<0.001).
conclusionThe thickness of the protective epidermal barrier is, in itself, a potential marker of pregnancy dating. However, sets of values obtained from skin morphometry enhanced the estimation of the gestational age. Such findings may support non-invasive image approaches to estimate pregnancy dating with various clinical applications.
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