Evidence map›Paper›PMID 34876273›Full record

ArticleTalanta2022

Diagnostics of SARS-CoV-2 infection using electrical impedance spectroscopy with an immunosensor to detect the spike protein.

Juliana C Soares, Andrey C Soares, Monara Kaelle S C Angelim, Jose Luiz Proença-Modena, Pedro M Moraes-Vieira, Luiz H C Mattoso, Osvaldo N Oliveira

Open access · greenAbstract read
In one paragraph

Article in Talanta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Juliana C SoaresSão Carlos Institute of Physics (IFSC), University of São Paulo (USP), 13566-590, São Carlos, Brazil.
Andrey C SoaresNanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentação, 13560-970, São Carlos, SP, Brazil.
Monara Kaelle S C AngelimDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, 13083-862, Campinas, SP, Brazil.
Jose Luiz Proença-ModenaDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, 13083-862, Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, 13083-862, Campinas, SP, Brazil.
Pedro M Moraes-VieiraDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, 13083-862, Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, 13083-862, Campinas, SP, Brazil; Obesity and Comorbilities Research Center (OCRC), University of Campinas, 13083-862, Campinas, SP, Brazil.
Luiz H C MattosoNanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentação, 13560-970, São Carlos, SP, Brazil.
Osvaldo N OliveiraSão Carlos Institute of Physics (IFSC), University of São Paulo (USP), 13566-590, São Carlos, Brazil. Electronic address: chu@ifsc.usp.br.
Universidade Estadual de Campinas (UNICAMP) · BRBrazilian Agricultural Research Corporation · BRUniversidade Federal de São Carlos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mass testing for the diagnostics of COVID-19 has been hampered in many countries owing to the high cost of the methodologies to detect genetic material of SARS-CoV-2. In this paper, we report on a low-cost immunosensor capable of detecting the spike protein of SARS-CoV-2, including in samples of inactivated virus. Detection is performed with electrical impedance spectroscopy using an immunosensor that contains a monolayer film of carboxymethyl chitosan as matrix, coated with an active layer of antibodies specific to the spike protein. In addition to a low limit of detection of 0.179 fg/mL within an almost linear behavior from 10

Indexed as

Biosensing TechniquesCOVID-19Dielectric SpectroscopyHumansImmunoassaySARS-CoV-2Spike Glycoprotein, CoronavirusSpike Glycoprotein, CoronavirusImmunosensorsImpedance spectroscopyInformation visualizationSARS-CoV-2Spike protein

Identifiers

PMID34876273
PMCPMC8607795
OpenAlexW3215006494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.