Evidence map›Paper›PMID 34876244›Full record

Observational studyMaturitas2022

The association of parity and breastfeeding with anti-Müllerian hormone levels at two time points.

Nydjie P Grimes, Brian W Whitcomb, Katherine W Reeves, Lynnette L Sievert, Alexandra Purdue-Smithe, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Elizabeth R Bertone-Johnson

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Maturitas, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Nydjie P GrimesDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address: ngrimes@umass.edu.
Brian W WhitcombDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Katherine W ReevesDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Lynnette L SievertDepartment of Anthropology, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Alexandra Purdue-SmitheEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
JoAnn E MansonChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
Susan E HankinsonDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA 01003, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Bernard A RosnerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Elizabeth R Bertone-JohnsonDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA 01003, USA; Department of Health Promotion and Policy, University of Massachusetts Amherst, Amherst, MA 01003, USA.
University of Massachusetts Amherst · USBrigham and Women's Hospital · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USHarvard University · US

Funding

Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Predictors of Early MenopauseR01HD078517 · NICHD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI BERTONE-JOHNSON, ELIZABETH R · 2014 to 2018
$3.2M
NCI NIH HHS U01 CA176726NICHD NIH HHS R01 HD078517
6 · The paper itself

Abstract

objectiveTo evaluate the association between parity and breastfeeding and anti-Müllerian hormone levels (AMH) and change in AMH levels over time. Furthermore, we examined whether AMH levels mediate the relation of parity and breastfeeding with age at menopause. STUDY

designObservational, prospective cohort study.

main outcome measuresAMH levels were assessed in a subset of premenopausal participants in the Nurses' Health Study II, including 1619 women who provided a blood sample in 1996-1999 and an additional 800 women who provided a second premenopausal sample in 2010-2012.

resultsIn multivariable linear regression models adjusted for parity, body mass index, smoking, and other factors, mean log AMH levels in 1996-1999 were 39% higher in women reporting ≥25 months of total breastfeeding vs. <1 month (P for trend = 0.009). Parity was not associated with AMH levels after adjustment for breastfeeding. Neither parity nor breastfeeding was associated with decline in AMH levels over 11 to 15 years. Breastfeeding duration was positively associated with age at menopause (P for trend = 0.01), with evidence that the association was mediated via AMH.

conclusionsOur results suggest that breastfeeding is associated with higher AMH levels and later onset of menopause, and support the hypothesis that observed relations of parity with AMH levels and menopause timing may be largely attributable to breastfeeding.

Indexed as

Anti-Mullerian HormoneBreast FeedingParityFemaleHumansMenopausePregnancyProspective StudiesAnti-Mullerian HormoneAMHanti-Mullerian hormoneBreastfeedingParityWomen's health

Identifiers

PMID34876244
PMCPMC8665225
OpenAlexW3201561014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.