Evidence map›Paper›PMID 34876227›Full record

ArticleJournal of intensive care2021

Letter the editor: serious methodological concerns about a recently published meta-analysis on oxygen therapy.

Thomas Lass Klitgaard, Olav Lilleholt Schjørring, Frederik Mølgaard Nielsen, Christian Sylvest Meyhoff, Marija Barbateskovic, Jørn Wetterslev, Anders Perner, Bodil Steen Rasmussen

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Thomas Lass KlitgaardDepartment of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark. tlk@rn.dk.ORCID http://orcid.org/0000-0002-8781-1206
Olav Lilleholt SchjørringDepartment of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.
Frederik Mølgaard NielsenDepartment of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.
Christian Sylvest MeyhoffDepartment of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Marija BarbateskovicCopenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Jørn WetterslevCopenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Anders PernerDepartment of Intensive Care, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Bodil Steen RasmussenDepartment of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.
Aalborg University Hospital · DKCopenhagen University Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recent paper, Chen et al. report the findings of a systematic review with meta-analysis concerning conservative versus conventional oxygen therapy for critically ill patients. We wish to commend the authors for their interest in the matter. However, the authors appear to misquote findings, fail to report results for all specified analyses, do not identify all relevant trials, have post hoc changed the eligibility criteria, and have seemingly switched directions of effects in analyses of secondary outcomes. These issues have led to incorrect conclusions concerning the effects of targeted oxygen therapy in critically ill patients.

Indexed as

Critical careMeta-analysisOxygenSystematic review

Identifiers

PMID34876227
PMCPMC8649324
OpenAlexW4200499250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.