ArticleFluids and barriers of the CNS2021
Quantitative analysis of macroscopic solute transport in the murine brain.
Article in Fluids and barriers of the CNS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- In-silico solute transport via perivascular networks in the human intracranial space.Nature communications · 2026Article
- MR-AIV reveals in vivo brain-wide fluid flow with physics-informed AI.Science advances · 2026Article
- Robust MR-AIV: A Systematic Study of Robustness Improvement and Sensitivity Analysis of MR-AIV.bioRxiv : the preprint server for biology · 2026Article
- New integrated three-interface conceptual model for clearance and immune surveillance in the human CNS.Frontiers in cell and developmental biology · 2026Review
- Review
- Glymphatic Clearance in the Optic Nerve: A Multidomain Electro-Osmostic Model.Entropy (Basel, Switzerland) · 2025Article
- MR-AIV revealsbioRxiv : the preprint server for biology · 2025Article
- Advection and diffusion in perivascular and extracellular spaces in the brain.Journal of the Royal Society, Interface · 2025Article
- A brain-wide solute transport model of the glymphatic system.Journal of the Royal Society, Interface · 2024Article
- Modeling of brain efflux: Constraints of brain surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Image-guided subject-specific modeling of glymphatic transport and amyloid deposition.Computer methods in applied mechanics and engineering · 2023Article
- Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation.Fluids and barriers of the CNS · 2023Article
- Sizes and shapes of perivascular spaces surrounding murine pial arteries.Fluids and barriers of the CNS · 2023Article
- Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space-A computational study.PLoS computational biology · 2023Article
- Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain.Fluids and barriers of the CNS · 2023Article
- Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries.Research square · 2023Article
- Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Investigating molecular transport in the human brain from MRI with physics-informed neural networks.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundUnderstanding molecular transport in the brain is critical to care and prevention of neurological disease and injury. A key question is whether transport occurs primarily by diffusion, or also by convection or dispersion. Dynamic contrast-enhanced (DCE-MRI) experiments have long reported solute transport in the brain that appears to be faster than diffusion alone, but this transport rate has not been quantified to a physically relevant value that can be compared to known diffusive rates of tracers.
methodsIn this work, DCE-MRI experimental data is analyzed using subject-specific finite-element models to quantify transport in different anatomical regions across the whole mouse brain. The set of regional effective diffusivities ([Formula: see text]), a transport parameter combining all mechanisms of transport, that best represent the experimental data are determined and compared to apparent diffusivity ([Formula: see text]), the known rate of diffusion through brain tissue, to draw conclusions about dominant transport mechanisms in each region.
resultsIn the perivascular regions of major arteries, [Formula: see text] for gadoteridol (550 Da) was over 10,000 times greater than [Formula: see text]. In the brain tissue, constituting interstitial space and the perivascular space of smaller blood vessels, [Formula: see text] was 10-25 times greater than [Formula: see text].
conclusionsThe analysis concludes that convection is present throughout the brain. Convection is dominant in the perivascular space of major surface and branching arteries (Pe > 1000) and significant to large molecules (> 1 kDa) in the combined interstitial space and perivascular space of smaller vessels (not resolved by DCE-MRI). Importantly, this work supports perivascular convection along penetrating blood vessels.
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