ArticleWorld journal of surgical oncology2021
Anemia can predict the prognosis of colorectal cancer in the pre-operative stage: a retrospective analysis.
Article in World journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment.Frontiers in oncology · 2022Pooled it
- Beyond Simple Ratios: Can the Preoperative HALP Score Provide a More Effective Inflammatory Biomarker for Colon Cancer Survival?Medicina (Kaunas, Lithuania) · 2026Article
- Anemia-Related Red Flags as Distinctive Early Indicators for Colorectal Cancer Diagnosis in Older Adults.Journal of clinical medicine · 2026Article
- Interpretable machine learning enables early identification of financial risk and resource optimization in colorectal cancer surgery.Frontiers in public health · 2026Article
- Correlation between clinical features, medical history, and lifestyle factors with colorectal cancer stage.Future science OA · 2025Article
- Serum hepcidin concentration is lower in advanced stages of sporadic colorectal cancer.Biochemia medica · 2025Article
- Sex Hormones and Iron-Related Biomarkers Associate with EMT Features and Tumor Stage in Colorectal Cancer: A Serum- and Tissue-Based Analysis.International journal of molecular sciences · 2025Article
- Impact of iron-deficiency anemia on short-term outcomes after resection of colorectal cancer liver metastasis: a US National (Nationwide) Inpatient Sample (NIS) analysis.Annals of coloproctology · 2025Article
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- Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment.World journal of clinical oncology · 2024Article
- Neoadjuvant chemotherapy-induced hemoglobin decline as a prognostic factor in osteosarcoma around the knee joint: a single-center retrospective analysis of 242 patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- In-Hospital Mortality and Associated Factors among Colorectal Cancer Patients in Germany.Cancers · 2024Article
- Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival.Scientific reports · 2024Article
- Anemia and Iron Deficiency Predict All-Cause Mortality in Patients with Heart Failure and Preserved Ejection Fraction: 6-Year Follow-Up Study.Diagnostics (Basel, Switzerland) · 2024Article
- Erythropoiesis in Cushing syndrome: sex-related and subtype-specific differences. Results from a monocentric study.Journal of endocrinological investigation · 2024Article
- The association between objectively measured preoperative light-intensity physical activity and postoperative ambulation in patients with gastrointestinal cancer.Journal of physical therapy science · 2024Article
- Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases.Journal of clinical medicine · 2023Article
- Clinical presentation, treatment patterns, and outcomes of colorectal cancer patients at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia: A prospective cohort study.Cancer reports (Hoboken, N.J.) · 2023Article
- Prognostic value of EBV DNA and platelet-to-lymphocyte ratio in patients with non-metastatic nasopharyngeal carcinoma: a retrospective study.BMC cancer · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundEarly detection of colorectal cancer (CRC) improves prognosis, yet many CRCs are diagnosed following symptoms. The aim of this study was to determine which CRC-related symptoms or signs can predict an advanced CRC in the pre-operative stage.
methodsRetrospective analysis of 300 patients who underwent surgery for CRC between the years 2008 and 2019. Patients' symptoms prior to CRC diagnosis were documented. Primary endpoint was the association of signs or/and symptoms with CRC diagnosis at TNM stages of 2-4 (i.e., highly advanced), compared to TNM score of 0-1 (i.e., locally advanced).
resultsThree hundred patients, 91 with locally advanced and 209 with highly advanced CRC, were enrolled. There was a significant correlation between highly advanced CRC, compared to locally advanced, regarding tumor size (4.8 vs. 2.6 cm, p<0.001), presentation of any symptom prior to diagnosis (77% vs. 54%, p<0.001), anemia (46% vs. 29%, p=0.004), and severe anemia (17% vs. 4%, p=0.002). Mean hemoglobin was 12.2 ± 2.2 and 13.1 ± 1.8 in the highly advanced compared to locally advanced CRC, respectively, p<0.001. Anemia correlated with the T stage of the tumor: 21% of patients diagnosed at stages 0-1 had anemia, 39% at stage 2, 44% at stage 3, and 66% at stage 4 (p=0.001).
conclusionsAnemia is the only finding that correlates with highly advanced CRC, in the pre-operative stage. When CRC has been diagnosed, the presence of anemia, at any level, may be considered in determining prognosis at the pre-operative stage. Physicians should be aware that when anemia is present, the risk for highly advanced CRC increases, and therefore should pursue with CRC detection.
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