ArticleBMC neuroscience2021
Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction.
Article in BMC neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Changes in Functional Brain Activity in School-Age Children 10 Years Later: A Resting State Functional Magnetic Resonance Imaging Study.Psychiatry investigation · 2026Article
- Disrupted structural covariance network in presbycusis patients: evidence from a large sample mri-based morphometric study.Frontiers in aging neuroscience · 2026Article
- The relationship between sarcopenia and mental health status in Chinese older adults: the mediating role of activities of daily living.BMC geriatrics · 2025Article
- Neuroanatomy, episodic memory and inhibitory control of persian-kurdish simultaneous bilinguals.Scientific reports · 2024Article
- Influence of intergenerational social mobility on brain structure and global cognition: findings from the Whitehall II study across 20 years.Age and ageing · 2024Article
- Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization.Brain communications · 2024Article
- Assessment of cognitive function and sleep-wake rhythms in community-dwelling older adults.Sleep and biological rhythms · 2024Article
- Association Between Ultra-Processed Food Consumption and Cognitive Performance Among Adolescent Students From Underdeveloped Cities in Brazil: A Cross-Sectional Study.International journal of public health · 2024Article
- Deficits of Visual Cortex Function in Acute Acquired Concomitant Esotropia Patients.Investigative ophthalmology & visual science · 2023Article
- Effects of gastrodin on the expression of brain aging-related genes in SAM/P-8 mice based on network pharmacology.Ibrain · 2023Article
- Apolipoprotein E knockout may affect cognitive function in D-galactose-induced aging mice through the gut microbiota-brain axis.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive function declines with age and has been shown to be associated with atrophy in some brain regions, including the prefrontal cortex. However, the details of the relationship between aging and cognitive dysfunction are not well understood.
methodsAcross a wide range of ages (24- to 85-years-old), this research measured the gray matter volume of structural magnetic resonance imaging data in 39 participants, while some brain regions were set as mediator variables to assess the cascade process between aging and cognitive dysfunction in a path analysis.
resultsPath analysis showed that age affected the left hippocampus, thereby directly affecting the left superior frontal gyrus. Furthermore, the gyrus directly affected higher order flexibility and maintenance abilities calculated as in the Wisconsin card sorting test, and the two abilities affected the assessment of general cognitive function.
conclusionOur finding suggests that a cascade process mediated by the left hippocampus and left superior frontal gyrus is involved in the relationship between aging and cognitive dysfunction.
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