Evidence map›Paper›PMID 34875875›Full record

ArticleEpigenomics2022

Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis.

Clarisse Musanabaganwa, Agaz H Wani, Janelle Donglasan, Segun Fatumo, Stefan Jansen, Jean Mutabaruka, Eugene Rutembesa, Annette Uwineza, Erno J Hermans, Benno Roozendaal and 3 more

Open access · greenAbstract read
In one paragraph

Article in Epigenomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Genetic heritage of war: exploring transgenerational inheritance of PTSD and its molecular background.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. InvestigatingBrain sciences · 2025
    Article
  8. Article
  9. Article
  10. Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 5 countries.

Clarisse MusanabaganwaCentre for Human Genetics, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda.ORCID 0000-0002-9006-8310
Agaz H WaniGenomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-0540-2952
Janelle DonglasanGenomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-3147-0449
Segun FatumoLondon School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0003-4525-3362
Stefan JansenDirectorate of Research & Innovation, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda.ORCID 0000-0001-5293-1673
Jean MutabarukaDepartment of Clinical Psychology, College of Medicine & Health Sciences, University of Rwanda, Huye, Rwanda.ORCID 0000-0001-9266-416X
Eugene RutembesaDepartment of Clinical Psychology, College of Medicine & Health Sciences, University of Rwanda, Huye, Rwanda.ORCID 0000-0003-3789-3538
Annette UwinezaCentre for Human Genetics, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda.ORCID 0000-0003-1749-0395
Erno J HermansDepartment of Cognitive Neuroscience, Radboud University Medical Center - Donders Institute for Brain, Cognition & Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0003-1339-8639
Benno RoozendaalDepartment of Cognitive Neuroscience, Radboud University Medical Center - Donders Institute for Brain, Cognition & Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0001-7013-2111
Derek E WildmanGenomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-6374-5136
Leon MutesaCentre for Human Genetics, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda.ORCID 0000-0002-5308-3706
Monica UddinGenomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.ORCID 0000-0001-7404-2068
University of Rwanda · RWUniversity of South Florida · USRadboud University Nijmegen · NLLondon School of Hygiene & Tropical Medicine · GB

Funding

Transgenerational Epigenomics of Trauma and PTSD in RwandaU01MH115485 · NIMH · NATIONAL UNIVERSITY OF RWANDA · PI JANSEN, STEFAN, MUTESA, LEON · 2017 to 2021
$1.3M
NIMH NIH HHS U01 MH115485
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GenocideStress Disorders, Post-TraumaticChildDNA MethylationEpigenomeFemaleHumansLeukocytesPregnancyRwandaSurvivorsdifferentially methylated regionepigeneticsepigenomicgenocideintergenerational transmissionmaternal stressmethylationoffspringPTSDtrauma

Identifiers

PMID34875875
PMCPMC8672329
OpenAlexW4200381659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.