ArticleCirculation. Cardiovascular imaging2021
Right Heart Dysfunction in Adults With Coarctation of Aorta: Prevalence and Prognostic Implications.
Article in Circulation. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 32 citations in OpenAlex.
- Prognostic Implication of Heart Failure With Reduced and Midrange Ejection Fraction in Adults With Congenital Heart Disease.CJC pediatric and congenital heart disease · 2026Article
- Prognostic value of right ventricular-pulmonary arterial coupling in adults with repaired coarctation of aorta.International journal of cardiology. Congenital heart disease · 2025Article
- Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta.International journal of cardiology. Heart & vasculature · 2025Article
- Incidence, Correlates, and Prognostic Implications of New-Onset Atrial Fibrillation in Adults With Repaired Coarctation of Aorta.CJC pediatric and congenital heart disease · 2024Article
- Article
- Cardiac Reverse Remodeling and Changes in Heart Failure Indices After Transcatheter Tricuspid Valve Replacement in Adults With Congenital Heart Disease.Circulation. Cardiovascular interventions · 2024Article
- Prognostic Value of the Anatomic-Physiologic Classification in Adults With Congenital Heart Disease.Circulation. Heart failure · 2023Article
- Prognostic Role of Tricuspid Annular Plane Systolic Excursion/Right Ventricular Systolic Pressure Ratio in Coarctation of Aorta.CJC pediatric and congenital heart disease · 2023Article
- Right Ventricular Function and Right Ventricular-Vascular Coupling Assessment After Coarctation Repair in Adults.CJC pediatric and congenital heart disease · 2023Article
- Coarctation of the Aorta: Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
- Prognostic Value of the HJACC. Advances · 2022Article
- Role of Inferior Vena Cava Dynamics for Estimating Right Atrial Pressure in Congenital Heart Disease.Circulation. Cardiovascular imaging · 2022Article
- Evaluation of Subclinical Right Ventricular Dysfunction in Adults with Repaired Aortic Coarctation.Journal of cardiovascular echographyArticle
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4 authors at 1 institution in 1 country.
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Abstract
backgroundChronic elevation of left heart filling pressure causes pulmonary vascular remodeling, pulmonary hypertension, and right heart dysfunction. Although diastolic dysfunction is relatively common in patients with coarctation of aorta, there are limited data about the prevalence and prognostic implications of pulmonary hypertension and right heart dysfunction in this population. The purpose of the study was to assess right heart function and hemodynamics in patients with coarctation of aorta and to determine the relationship between right heart indices and cardiovascular events defined as heart failure hospitalization, heart transplant, or cardiovascular death.
methodsRight heart structure, function, and hemodynamics were assessed with these indices: right atrial volume, right atrial pressure, right atrial reservoir strain, right ventricular global longitudinal strain, right ventricular end-diastolic area, right ventricular systolic pressure, and tricuspid regurgitation severity. Right heart hemodynamic score, range 0 to 5, was generated based on the correlation between the right heart indices and cardiovascular events, using half of the cohort (derivation cohort, n=411), and then tested on the validation cohort (n=410). The goodness of fit and discrimination power was compared using C statistics and risk score.
resultsThe median follow-up in the derivation cohort was 8.2 (4.0-11.1) years, and 59 (14%) patients had cardiovascular events during this period. Right heart hemodynamic score was independently associated with cardiovascular events (hazard ratio, 1.64 [95% CI, 1.38-2.17]) for every unit increase in right heart hemodynamic score after adjustment for clinical and echocardiographic indices (C statistic, 0.718 [95% CI, 0.682-0.746]). The right heart hemodynamic score was also independently associated with cardiovascular events in the validation cohort (C statistic, 0.711 [95% CI, 0.679-0.741]). The C statistic difference (0.007 [95% CI, 0.014-0.022]) and risk score (0.86 [95% CI, 0.54-1.17]) suggest a good model fit.
conclusionsThe current study underscores the prognostic importance of right heart dysfunction in patients with coarctation of aorta and suggests that right heart indices should be used for risks stratification in this population.
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