ArticleClinical and experimental reproductive medicine2021
The antioxidant roles of L-carnitine and N-acetyl cysteine against oxidative stress on human sperm functional parameters during vitrification.
Article in Clinical and experimental reproductive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Algal and Fungal Antioxidants Alleviate Oxidative Stress-Induced Reproductive Defects.Food science & nutrition · 2025Review
- Advancements in Understanding and Enhancing Antioxidant-Mediated Sperm Cryopreservation in Small Ruminants: Challenges and Perspectives.Antioxidants (Basel, Switzerland) · 2024Review
- Cadmium as a male reproductive toxicant and natural and non-natural ways to tackle it: a review.Environmental science and pollution research international · 2024Review
- The protective effect of zinc oxide and selenium oxide nanoparticles on the functional parameters of rat sperm during vitrification.Clinical and experimental reproductive medicine · 2024Article
- Detrimental impact of cell phone radiation on sperm DNA integrity.Clinical and experimental reproductive medicine · 2024Article
- Human sperm parameter improvement associated with Ceratonia siliqua extract as a cryopreservation supplement after vitrification.Clinical and experimental reproductive medicine · 2023Article
- Human Sperm as an In Vitro Model to Assess the Efficacy of Antioxidant Supplements during Sperm Handling: A Narrative Review.Antioxidants (Basel, Switzerland) · 2023Review
- Melatonin and selenium supplementation in extenders improves the post-thaw quality parameters of rat sperm.Clinical and experimental reproductive medicine · 2022Article
- Evaluation of L-Carnitine Potential in Improvement of Male Fertility.Journal of reproduction & infertilityReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAmino acids can protect sperm structure in cryopreservation due to their antioxidant properties. Therefore, the present study aimed to investigate the protective effect of L-carnitine (LC) and N-acetyl cysteine (NAC) on motility parameters, plasma membrane integrity (PMI), mitochondrial membrane potential (MMP), DNA damage, and human sperm intracellular reactive oxygen species (ROS) during vitrification.
methodsTwenty normal human sperm samples were examined. Each sample was divided into six equal groups: LC (1 and 10 mM), NAC (5 and 10 mM), and cryopreserved and fresh control groups.
resultsThe groups treated with LC and NAC showed favorable findings in terms of motility parameters, DNA damage, and MMP. Significantly higher levels of intracellular ROS were observed in all cryopreserved groups than in the fresh group (p≤0.05). The presence of LC and NAC at both concentrations caused an increase in PMI, MMP, and progressive motility parameters, as well as a significant reduction in intracellular ROS compared to the control group (p≤0.05). The concentrations of the amino acids did not show any significant effect.
conclusionLC and NAC are promising as potential additives in sperm cryopreservation.
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