ArticleCerebral cortex (New York, N.Y. : 1991)2022
Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Diagnostic utility of electrophysiological markers for early and differential diagnosis of Alzheimer's, Frontotemporal, and Lewy Body dementias: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Functional and effective EEG connectivity patterns in Alzheimer's disease and mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.PLoS computational biology · 2026Article
- Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Digital language measures capture episodic memory disruptions in people with human immunodeficiency virus: A machine learning study.The Clinical neuropsychologist · 2026Article
- EENet-RLA: An Explainable Prediction Learning Framework for Alzheimer's Disease Classification from EEG Signals.Brain topography · 2026Article
- Loneliness exacerbates age differences in the -allostatic-interoceptive system during induced affect.Social cognitive and affective neuroscience · 2026Article
- Cognitive Phenotyping of Parkinson's Disease Patients Via Digital Analysis of Spoken Word Properties.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Neural dynamics of social verb processing: an MEG study.Social cognitive and affective neuroscience · 2025Article
- Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration.Current topics in behavioral neurosciences · 2025Review
- Emotional recognition technologies applied to health: review and challenges.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Review
- Current implications of EEG and fNIRS as functional neuroimaging techniques for motor recovery after stroke.Medical review (2021) · 2024Review
- Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Electrophysiological alterations during action semantic processing in Parkinson's disease.Neurobiology of aging · 2024Article
- Multivariate word properties in fluency tasks reveal markers of Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neurocognitive correlates of semantic memory navigation in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Automated free speech analysis reveals distinct markers of Alzheimer's and frontotemporal dementia.PloS one · 2024Article
- The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds.Scientific data · 2023Article
- Speech and language markers of neurodegeneration: a call for global equity.Brain : a journal of neurology · 2023Review
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 6 countries.
Funding
Abstract
Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson's disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer's disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action-text deficits related to the volume of action-observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social-text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer's disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.