Evidence map›Paper›PMID 34875674›Full record

ArticleNature2022

Multi-omic machine learning predictor of breast cancer therapy response.

Stephen-John Sammut, Mireia Crispin-Ortuzar, Suet-Feung Chin, Elena Provenzano, Helen A Bardwell, Wenxin Ma, Wei Cope, Ali Dariush, Sarah-Jane Dawson, Jean E Abraham and 11 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06681064 (Breast Cancer Evolution During Neoadjuvant Systemic Therapy), which is not on this map. Cited by 365 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
365citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06681064 recruitingnot on this mapstarted 2024, after this paper: background citation

Breast Cancer Evolution During Neoadjuvant Systemic Therapy

TypeobservationalSponsorRoyal Marsden NHS Foundation TrustRan2024 to 2034Enrolled500ConditionsBreast Cancer, Triple Negative Breast Cancer, ER+ Breast Cancer, HER2+ Breast Cancer
3 · Its place in the literature

Who cites it

365 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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305 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Stephen-John SammutCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID http://orcid.org/0000-0003-4472-904X
Mireia Crispin-Ortuzar *Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Suet-Feung Chin *Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID http://orcid.org/0000-0001-5697-1082
Elena ProvenzanoCRUK Cambridge Centre, Cambridge Experimental Cancer Medicine Centre (ECMC) and NIHR Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID http://orcid.org/0000-0003-3345-3965
Helen A BardwellCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Wenxin MaSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Wei CopeCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Ali DariushCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Sarah-Jane DawsonPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-8276-0374
Jean E AbrahamDepartment of Oncology, University of Cambridge, Cambridge, UK.
Janet DunnWarwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Louise HillerWarwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Jeremy ThomasEdinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4652-610X
David A CameronEdinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK.
John M S BartlettEdinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK.
Larry HaywardEdinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK.
Paul D PharoahCRUK Cambridge Centre, Cambridge Experimental Cancer Medicine Centre (ECMC) and NIHR Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID http://orcid.org/0000-0001-8494-732X
Florian MarkowetzCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID http://orcid.org/0000-0002-2784-5308
Oscar M RuedaCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID http://orcid.org/0000-0003-0008-4884
Helena M EarlDepartment of Oncology, University of Cambridge, Cambridge, UK.
Carlos CaldasCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. carlos.caldas@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0003-3547-1489

Funding

Cancer Research UK 16942Cancer Research UK 28290Cancer Research UK 29567European Research CouncilMedical Research Council MC_UU_00002/16Wellcome TrustWellcome Trust 106566/Z/14/Z
6 · The paper itself

Abstract

Breast cancers are complex ecosystems of malignant cells and the tumour microenvironment

Indexed as

Breast NeoplasmsEcosystemFemaleGenomicsHumansMachine LearningNeoadjuvant TherapyTumor Microenvironment

Identifiers

PMID34875674
PMCPMC8791834

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.