Evidence map›Paper›PMID 34875673›Full record

ArticleNature2022

Signature of long-lived memory CD8

Sarah Adamo, Jan Michler, Yves Zurbuchen, Carlo Cervia, Patrick Taeschler, Miro E Raeber, Simona Baghai Sain, Jakob Nilsson, Andreas E Moor, Onur Boyman

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 2 syntheses or guidelines pooled it, 152 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. CD8Cell reports. Medicine · 2026
    Review
  4. Distinct CD8iScience · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Adoptive T-cell therapy for virus-associated diseases.Clinical microbiology reviews · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Characterization of human CMV-specific CD8Cell reports methods · 2025
    Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sarah AdamoDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-6161-3156
Jan MichlerDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Yves ZurbuchenDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5387-9950
Carlo CerviaDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-7120-8739
Patrick TaeschlerDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.
Miro E RaeberDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-2609-0246
Simona Baghai SainDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Jakob NilssonDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland.
Andreas E MoorDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID http://orcid.org/0000-0001-8715-8449
Onur BoymanDepartment of Immunology, University Hospital Zurich, Zurich, Switzerland. onur.boyman@uzh.ch.ORCID http://orcid.org/0000-0001-8279-5545
University Hospital of Zurich · CHETH Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated and enhanced immune response upon re-infection with the same pathogen

Indexed as

Acute DiseaseAntigens, ViralBiomarkersCD8-Positive T-LymphocytesCell ProliferationClone CellsCOVID-19HumansInterferonsInterleukin-7 Receptor alpha SubunitLeukocyte Common AntigensLongitudinal StudiesMechanistic Target of Rapamycin Complex 1Memory T CellsReceptors, Antigen, T-CellReceptors, CCR7Antigens, ViralBiomarkersCCR7 protein, humanIL7R protein, humanInterferonsInterleukin-7 Receptor alpha SubunitLeukocyte Common AntigensMechanistic Target of Rapamycin Complex 1Receptors, Antigen, T-CellReceptors, CCR7T Cell Transcription Factor 1

Identifiers

PMID34875673
PMCPMC8810382
OpenAlexW4200022103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.