Evidence map›Paper›PMID 34875662›Full record

ArticleObesity facts2022

NPPA Promoter Hypomethylation Predicts Central Obesity Development: A Prospective Longitudinal Study in Chinese Adults.

Jing Li, Jinhua Zhu, Qiu Zhang, Linan Chen, Shengqi Ma, Ying Lu, Bin Shen, Rongyan Zhang, Mingzhi Zhang, Yan He and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity facts, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jing LiDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Jinhua ZhuDepartment of Chronic Disease Management, Center for Disease Prevention and Control of Wujiang District, Suzhou, China.
Qiu ZhangDepartment of Chronic Disease Management, Center for Disease Prevention and Control of Gusu District, Suzhou, China.
Linan ChenDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Shengqi MaDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Ying LuDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Bin ShenDepartment of Chronic Disease Management, Center for Disease Prevention and Control of Wujiang District, Suzhou, China.
Rongyan ZhangDepartment of Chronic Disease Management, Center for Disease Prevention and Control of Wujiang District, Suzhou, China.
Mingzhi ZhangDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Yan HeDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Lei WuDepartment of Maternal and Child Health, Suzhou Industrial Park Center for Disease Control and Prevention, Suzhou, China.
Hao PengDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAtrial natriuretic peptide plays a potential role in obesity with unclear molecular mechanisms. The objective of this study was to examine the association between its coding gene (natriuretic peptide A [NPPA]) methylation and obesity.

methodsPeripheral blood DNA methylation of NPPA promoter was quantified at baseline by targeted bisulfite sequencing for 2,497 community members (mean aged 53 years, 38% men) in the Gusu cohort. Obesity was repeatedly assessed by body mass index (BMI) and waist circumference (WC) at baseline and follow-up examinations. The cross-sectional, longitudinal, and prospective associations between NPPA promoter methylation and obesity were examined.

resultsOf the 9 CpG loci assayed, DNA methylation levels at 6 CpGs were significantly lower in participants with central obesity than those without (all p < 0.05 for permutation test). These CpG methylation levels at baseline were also inversely associated with dynamic changes in BMI or WC during follow-up (all p < 0.05 for permutation test). After an average 4 years of follow-up, hypermethylation at the 6 CpGs (CpG2 located at Chr1:11908348, CpG3 located at Chr1:11908299, CpG4 located at Chr1:11908200, CpG5 located at Chr1:11908182, CpG6 located at Chr1:11908178, and CpG8 located at Chr1:11908165) was significantly associated with a lower risk of incident central obesity (all p < 0.05 for permutation test).

conclusionsHypomethylation at NPPA promoter was associated with increased future risk of central obesity in Chinese adults. Aberrant DNA methylation of the NPPA gene may participate in the mechanisms of central obesity.

Indexed as

DNA MethylationObesity, AbdominalAtrial Natriuretic FactorBody Mass IndexChinaCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedObesityProcainamideAtrial Natriuretic FactorNPPA protein, humanN-propionylprocainamideProcainamideAtrial natriuretic peptideCentral obesityDNA methylation

Identifiers

PMID34875662
PMCPMC9021652
OpenAlexW4200610737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.