Evidence map›Paper›PMID 34875048›Full record

ArticleEuropean heart journal2022

Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society.

Frederikus A Klok, Walter Ageno, Cihan Ay, Magnus Bäck, Stefano Barco, Laurent Bertoletti, Cecilia Becattini, Jørn Carlsen, Marion Delcroix, Nick van Es and 8 more

2 registry-linked trialsOpen access · hybridAbstract readConsensus Statement
In one paragraph

Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06350331 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Smart Technology Facilitated Patient-centered Venous Thromboembolism Management: A Randomised Controlled Trial

TypeinterventionalSponsorNavy General Hospital, BeijingRan2024 to 2025Enrolled256ConditionsVenous Thromboembolism, Digital Health, Health EducationArmsmobile venous thromboembolism application (mVTEA)
NCT07143539 narecruitingnot on this mapstarted 2025, after this paper: background citation

Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism: a Pragmatic Multicenter Randomized Partially Blinded Superiority Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2025 to 2028Enrolled160ConditionsVenous Thromboembolism (VTE), Exercise Therapy, Quality of Life (QOL), Anxiety DepressionArmsExercise-based rehabilitation program
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 176 citations in OpenAlex.

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  17. Capturing the late complications of venous thromboembolism.Research and practice in thrombosis and haemostasis · 2026
    Review
  18. Review
  19. Article
  20. Fatigue after pulmonary embolism-prevalence and predictors.Frontiers in cardiovascular medicine · 2026
    Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 17 institutions in 14 countries.

Frederikus A KlokDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-9961-0754
Walter AgenoDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Cihan AyClinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2607-9717
Magnus BäckCenter for Molecular Medicine and Department of Cardiology, Karolinska University Hospital, Solna, Sweden, Stockholm.ORCID 0000-0003-0853-5141
Stefano BarcoCenter for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.ORCID 0000-0002-2618-347X
Laurent BertolettiService de Médecine Vasculaire et Thérapeutique, CHU de St-Etienne, Saint-Etienne 42055, France.ORCID 0000-0001-8214-3010
Cecilia BecattiniInternal and Cardiovascular Medicine-Stroke Unit, University of Perugia, Perugia, Italy.ORCID 0000-0002-8343-4888
Jørn CarlsenDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0003-0389-5957
Marion DelcroixClinical Dept. of Respiratory Diseases, Pulmonary Hypertension Center, UZ Leuven, Leuven, Belgium.ORCID 0000-0001-8394-9809
Nick van EsDepartment of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, Amsterdam, Netherlands.ORCID 0000-0001-5256-6346
Menno V HuismanDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, Netherlands.
Luis Jara-PalomaresMedical Surgical Unit of Respiratory Diseases, Instituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocio, Seville, Spain.ORCID 0000-0002-4125-3376
Stavros KonstantinidesCenter for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.ORCID 0000-0001-6359-7279
Irene LangDepartment of Internal Medicine II, Cardiology and Center of Cardiovascular Medicine, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria.ORCID 0000-0003-0485-2692
Guy MeyerRespiratory Medicine Department, Hôpital Européen Georges Pompidou, Aphp, Paris, France.
Fionnuala Ní ÁinleDept. of Hematology, Mater University Hospital and Rotunda Hospital, Dublin, Ireland.ORCID 0000-0003-0163-792X
Stephan RosenkranzDept. of Cardiology, Heart Center at the University of Cologne, Germany.ORCID 0000-0001-6237-1470
Piotr PruszczykDept. of Internal Medicine and Cardiology Medical University of Warsaw, Lindley St 4, Warsaw 00-005, Poland.ORCID 0000-0002-9768-0000
Johannes Gutenberg University Mainz · DEAmsterdam University Medical Centers · NLCentre Hospitalier Universitaire de Saint-Étienne · FRDélégation Paris 5 · FRDemocritus University of Thrace · GRInstituto de Salud Carlos III · ESKarolinska University Hospital · SEKU Leuven · BELeiden University Medical Center · NLMedical University of Vienna · ATMedical University of Warsaw · PLSechenov University · RUTH Köln - University of Applied Sciences · DEUniversity College Dublin · IEUniversity of Copenhagen · DKUniversity of Insubria · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This position paper provides a comprehensive guide for optimal follow-up of patients with acute pulmonary embolism (PE), covering multiple relevant aspects of patient counselling. It serves as a practical guide to treating patients with acute PE complementary to the formal 2019 European Society of Cardiology guidelines developed with the European Respiratory Society. We propose a holistic approach considering the whole spectrum of serious adverse events that patients with acute PE may encounter on the short and long run. We underline the relevance of assessment of modifiable risk factors for bleeding, of acquired thrombophilia and limited cancer screening (unprovoked PE) as well as a dedicated surveillance for the potential development of chronic thromboembolic pulmonary hypertension as part of routine practice; routine testing for genetic thrombophilia should be avoided. We advocate the use of outcome measures for functional outcome and quality of life to quantify the impact of the PE diagnosis and identify patients with the post-PE syndrome early. Counselling patients on maintaining a healthy lifestyle mitigates the risk of the post-PE syndrome and improves cardiovascular prognosis. Therefore, we consider it important to discuss when and how to resume sporting activities soon after diagnosing PE. Additional patient-relevant topics that require Focused counselling are travel and birth control.

Indexed as

AtherosclerosisCardiologyPulmonary EmbolismBiologyFollow-Up StudiesHumansPulmonary CirculationQuality of LifeVentricular Function, RightAnticoagulation therapyBleedingCardiovascular diseasesContraceptive agentsNeoplasmsPulmonary embolismPulmonary hypertensionSportsThrombophiliaTravel

Identifiers

PMID34875048
PMCPMC8790766
OpenAlexW4200254371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.