Evidence map›Paper›PMID 34875037›Full record

ArticleBlood2022

Age-related diseases of inflammation in myelodysplastic syndrome and chronic myelomonocytic leukemia.

Lachelle D Weeks, Catherine R Marinac, Robert Redd, Gregory Abel, Amy Lin, Mridul Agrawal, Richard M Stone, Deborah Schrag, Benjamin L Ebert

Abstract readComparative Study
In one paragraph

Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Expert Perspective: Hematologic Malignancies and Vasculitis.Arthritis & rheumatology (Hoboken, N.J.) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Mutational landscape and impact of clonal hematopoiesis of indeterminate potential in severe aortic valve stenosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Genetic variation across and within individuals.Nature reviews. Genetics · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lachelle D WeeksDepartment of Medical Oncology.ORCID 0000-0001-8726-6212
Catherine R MarinacCenter for Prevention of Progression.ORCID 0000-0002-9128-3012
Robert ReddDivision of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-1329-5288
Gregory AbelDivision of Population Sciences, Department of Medical Oncology.
Amy LinCenter for Prevention of Progression.ORCID 0000-0002-0554-2832
Mridul AgrawalDepartment of Medical Oncology.
Richard M StoneDivision of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA.
Deborah SchragDivision of Population Sciences, Department of Medical Oncology.
Benjamin L EbertDepartment of Medical Oncology.ORCID 0000-0003-0197-5451

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Targeting SYK Kinase in AMLP50CA206963 · NCI · DANA-FARBER CANCER INST · PI ASTER, JON C. · 2017 to 2021
$10.6M
Tyrosine Kinases, Serine-Threonine Kinases,&Phosophatases in PathogenesisP01CA108631 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ESTEY, ELIHU · 2005 to 2009
$9.7M
Training Program in Molecular HematologyT32HL116324 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI NANCY BERLINER · 2013 to 2026
$7.4M
Functional Genomic Dissection of Refractory AnemiaR01HL082945 · NHLBI · DANA-FARBER CANCER INSTITUTE · PI EBERT, BENJAMIN LEVINE · 2005 to 2022
$6.8M
The role of clonal hematopoiesis in the development and therapy of myeloid malignanciesR35CA253125 · NCI · DANA-FARBER CANCER INST · PI EBERT, BENJAMIN LEVINE · 2020 to 2024
$4.9M
Repurposing Metformin for the Prevention of Disease Progression in Precursor Multiple MyelomaK22CA251648 · NCI · DANA-FARBER CANCER INST · PI MARINAC, CATHERINE · 2020 to 2022
$577k
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS K22 CA251648NCI NIH HHS P01 CA066996NCI NIH HHS P01 CA108631NCI NIH HHS P50 CA206963NCI NIH HHS R35 CA253125NHLBI NIH HHS R01 HL082945NHLBI NIH HHS T32 HL116324
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hematopoietic Stem CellsLeukemia, Myelomonocytic, ChronicMutationMyelodysplastic SyndromesAgedAged, 80 and overAgingFemaleHumansInflammationMale

Identifiers

PMID34875037
PMCPMC8874362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.