ArticleCerebral cortex (New York, N.Y. : 1991)2022
Functional connectivity for the language network in the developing brain: 30 weeks of gestation to 30 months of age.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of interactive reading on young children's narrative abilities: a meta-analytic study.Frontiers in psychology · 2025Pooled it
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- Language network functional connectivity in infancy predicts developmental language trajectories.Developmental cognitive neuroscience · 2026Article
- Maternal Cardiovascular Health During Pregnancy and Offspring Developmental Delay.JAMA network open · 2026Article
- Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.Developmental cognitive neuroscience · 2026Review
- Shared and Unique Connectivity Signatures of Reading and Language Deficits.Journal of cognitive neuroscience · 2026Article
- Utilizing functional neuroimaging to study early language development.Developmental cognitive neuroscience · 2025Review
- Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Prenatal brain connectivity and postnatal language: how familial risk and prenatal speech exposure shape early language skills.Scientific reports · 2025Article
- Language network functional connectivity in infancy predicts developmental language trajectories.bioRxiv : the preprint server for biology · 2025Article
- Precision fMRI reveals that the language network exhibits adult-like left-hemispheric lateralization by 4 years of age.bioRxiv : the preprint server for biology · 2025Article
- Language Functional Connectivity Alterations During Resting State in Brain Arteriovenous Malformation Patients.CNS neuroscience & therapeutics · 2025Article
- Asymmetric Inter-Hemisphere Communication Contributes to Speech Acquisition of Toddlers with Cochlear Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Lateralization of Neural Speech Discrimination at Birth Is a Predictor for Later Language Development.Developmental science · 2025Article
- Specialization of the brain for language in children with Fragile X Syndrome: a functional Near Infrared Spectroscopy study.Journal of neurodevelopmental disorders · 2024Article
- Brain age prediction and deviations from normative trajectories in the neonatal connectome.Nature communications · 2024Article
- Advances in Fetal Brain Imaging.Magnetic resonance imaging clinics of North America · 2024Review
- Longitudinal associations between language network characteristics in the infant brain and school-age reading abilities are mediated by early-developing phonological skills.Developmental cognitive neuroscience · 2024Article
- Longitudinal associations between language network characteristics in the infant brain and school-age reading abilities are mediated by early-developing phonological skills.bioRxiv : the preprint server for biology · 2024Article
- Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Although the neural scaffolding for language is putatively present before birth, the maturation of functional connections among the key nodes of the language network, Broca's and Wernicke's areas, is less known. We leveraged longitudinal and cross-sectional data from three sites collected through six studies to track the development of functional circuits between Broca's and Wernicke's areas from 30 weeks of gestation through 30 months of age in 127 unique participants. Using resting-state fMRI data, functional connectivity was calculated as the correlation between fMRI time courses from pairs of regions, defined as Broca's and Wernicke's in both hemispheres. The primary analysis evaluated 23 individuals longitudinally imaged from 30 weeks postmenstrual age (fetal) through the first postnatal month (neonatal). A secondary analysis in 127 individuals extended these curves into older infants and toddlers. These data demonstrated significant growth of interhemispheric connections including left Broca's and its homolog and left Wernicke's and its homolog from 30 weeks of gestation through the first postnatal month. In contrast, intrahemispheric connections did not show significant increases across this period. These data represent an important baseline for language systems in the developing brain against which to compare those neurobehavioral disorders with the potential fetal onset of disease.
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