ArticleCerebral cortex (New York, N.Y. : 1991)2022
It's in the Timing: Reduced Temporal Precision in Neural Activity of Schizophrenia.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Schizophrenia: temporal imprecision in phase, time, and frequency domains.Schizophrenia (Heidelberg, Germany) · 2026Article
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Diminished variability of alpha and beta band-limited power as a neural signature in schizophrenia.Translational psychiatry · 2026Article
- Learning evoked centrality dynamics in the schizophrenia brain: entropy, heterogeneity, and inflexibility of brain networks.Journal of psychiatry & neuroscience : JPN · 2025Article
- Temporal imprecision and its dynamics in schizophrenia.Translational psychiatry · 2025Article
- Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- Increased intra-subject variability in reward behavior relates to symptom severity in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Task difficulty modulates the effect of mind wandering on phase dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- What Constitutes the Personal Space in Schizophrenia? Converging Subjective Experience, Brain, and Social Environment.Schizophrenia bulletin · 2025Article
- From the brain's encoding of input dynamics to its behavior: neural dynamics shape bias in decision making.Communications biology · 2024Article
- Do smaller P300 amplitudes in schizophrenia result from larger variability in temporal processing?Schizophrenia (Heidelberg, Germany) · 2024Article
- Irregularity of visual motion perception and negative symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Is depression a global brain disorder with topographic dynamic reorganization?Translational psychiatry · 2024Review
- Limited Consistency and Strength of Neural Oscillations During Sustained Visual Attention in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Temporal imprecision of phase coherence in schizophrenia and psychosis-dynamic mechanisms and diagnostic marker.Molecular psychiatry · 2024Review
- Overcoming the translational crisis of contemporary psychiatry - converging phenomenological and spatiotemporal psychopathology.Molecular psychiatry · 2023Review
- Increased noise relates to abnormal excitation-inhibition balance in schizophrenia: a combined empirical and computational study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Integrating subjective and objective-spatiotemporal approach to psychiatric disorders.Molecular psychiatry · 2023Article
- Spatiotemporal Alterations in Working Memory-Related Beta Band Neuromagnetic Activity of Patients With Schizophrenia On and Off Antipsychotic Medication: Investigation With MEG.Schizophrenia bulletin · 2023Article
- Prolonged Intrinsic Neural Timescales Dissociate from Phase Coherence in Schizophrenia.Brain sciences · 2023Article
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7 authors.
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Abstract
Studies of perception and cognition in schizophrenia (SCZ) show neuronal background noise (ongoing activity) to intermittently overwhelm the processing of external stimuli. This increased noise, relative to the activity evoked by the stimulus, results in temporal imprecision and higher variability of behavioral responses. What, however, are the neural correlates of temporal imprecision in SCZ behavior? We first report a decrease in electroencephalography signal-to-noise ratio (SNR) in two SCZ datasets and tasks in the broadband (1-80 Hz), theta (4-8 Hz), and alpha (8-13 Hz) bands. SCZ participants also show lower inter-trial phase coherence (ITPC)-consistency over trials in the phase of the signal-in theta. From these ITPC results, we varied phase offsets in a computational simulation, which illustrated phase-based temporal desynchronization. This modeling also provided a necessary link to our results and showed decreased neural synchrony in SCZ in both datasets and tasks when compared with healthy controls. Finally, we showed that reduced SNR and ITPC are related and showed a relationship to temporal precision on the behavioral level, namely reaction times. In conclusion, we demonstrate how temporal imprecision in SCZ neural activity-reduced relative signal strength and phase coherence-mediates temporal imprecision on the behavioral level.
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