Evidence map›Paper›PMID 34874946›Full record

ArticlePloS one2021

Human milk-based fortifier is associated with less alteration of milk fat globule size than cow milk-based fortifier.

Yurika Yoshida, Minami Azuma, Haruhiro Kuwabara, Tokuo Miyazawa, Yuya Nakano, Kazuna Furukawa, Keli M Hawthorne, Masahiko Izumizaki, Takashi Takaki, Mari Sakaue and 1 more

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In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yurika YoshidaDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Minami AzumaDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Haruhiro KuwabaraDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Tokuo MiyazawaDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Yuya NakanoDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Kazuna FurukawaDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
Keli M HawthorneDepartment of Pediatrics, Dell Medical School, Dell Pediatric Research Institute, University of Texas at Austin, Austin, Texas.ORCID 0000-0001-6325-9827
Masahiko IzumizakiDepartment of Physiology, Showa University School of Medicine, Tokyo, Japan.
Takashi TakakiDivision of Electron Microscopy, Showa University School of Medicine, Tokyo, Japan.
Mari SakaueAnalysis Systems Solution Development Department, Hitachi High-Tech Corporation, Tokyo, Japan.
Katsumi MizunoDepartment of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to evaluate if human milk-based fortifier (HMBF) affects human milk fat globule (MFG) size less than cow milk-based fortifier (CMBF), which may impact overall infant feeding tolerance. Measurements of donated human milk were performed before fortification as well as at 1 hour, 24 hours, and 48 hours after fortification with CMBF or HMBF. MFG size in each sample of fortified milk was measured by laser light scattering. MFG size in the fortified milks increased gradually over time. At 24 and 48 hours after fortification, MFG size in the milk with CMBF was larger than that in the milk with HMBF (4.8 ± 0.5 vs 4.3 ± 0.3 μm, p<0.01, 5.1 ± 0.7 vs 4.5 ± 0.4 μm, p = 0.03, respectively). HMBF is associated with less alteration of MFG size than CMBF. This may have an impact on feeding tolerance of very preterm infants.

Indexed as

AnimalsCattleFemaleGlycolipidsGlycoproteinsHumansInfant, Extremely PrematureInfant, NewbornLipid DropletsMilk, HumanGlycolipidsGlycoproteinsmilk fat globule

Identifiers

PMID34874946
PMCPMC8651125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.