Evidence map›Paper›PMID 34874818›Full record

Trial reportAmerican journal of respiratory and critical care medicine2022

Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial.

Anthony D Postle, Howard W Clark, Jim Fink, Jens Madsen, Grielof Koster, Madhuriben Panchal, Ratko Djukanovic, David Brealey, Michael P W Grocott, Ahilanandan Dushianthan

Open access · hybridAbstract readLetterRandomized Controlled Trial
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Mechanistic Insights into Pulmonary Surfactant Inactivation.Langmuir : the ACS journal of surfaces and colloids · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.American journal of respiratory and critical care medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anthony D PostleUniversity of Southampton Southampton, United Kingdom.ORCID 0000-0001-7361-0756
Howard W ClarkUniversity College London Hospital London, United Kingdom.ORCID 0000-0001-7354-2028
Jim FinkAerogen Pharma Corporation San Mateo, California.ORCID 0000-0001-6527-2363
Jens MadsenUniversity College London London, United Kingdom.
Grielof KosterUniversity Hospital Southampton National Health System Foundation Trust Southampton, United Kingdom.ORCID 0000-0002-1761-969X
Madhuriben PanchalUniversity Hospital Southampton National Health System Foundation Trust Southampton, United Kingdom.
Ratko DjukanovicUniversity of Southampton Southampton, United Kingdom.ORCID 0000-0001-6039-5612
David BrealeyUniversity College Hospitals London London, United Kingdom.ORCID 0000-0002-1982-3379
Michael P W GrocottUniversity of Southampton Southampton, United Kingdom.ORCID 0000-0002-9484-7581
Ahilanandan DushianthanUniversity Hospital Southampton National Health System Foundation Trust Southampton, United Kingdom.ORCID 0000-0002-0165-3359
University Hospital Southampton NHS Foundation Trust · GBUniversity College Hospital · GBSan Mateo Medical Center · USUniversity College London · GB

Funding

Bill & Melinda Gates Foundation COVID-19 Aerosolized Surfactant Clinical TrialNational Institute of Health Research (NIHR) NIHR Southampton Biomedical Research Centre
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19 Drug TreatmentAdministration, InhalationBiomarkersCOVID-19HumansNebulizers and VaporizersPhospholipidsPilot ProjectsPulmonary SurfactantsRespiratory Distress SyndromeTreatment OutcomeBiomarkersPhospholipidsPulmonary SurfactantsSF-RI 1, bovine surfactant preparation

Identifiers

PMID34874818
PMCPMC8886955
OpenAlexW4200272869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.