Evidence map›Paper›PMID 34874731›Full record

ArticleThe Journal of organic chemistry2021

Silylpyrrole Oxidation En Route to Saxitoxin Congeners Including 11-Saxitoxinethanoic Acid.

Doris T Y Tang, Jeffrey E Merit, T Aaron Bedell, J Du Bois

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Doris T Y TangDepartment of Chemistry, Stanford University, 333 Campus Dr., Stanford, California 94305, United States.
Jeffrey E MeritDepartment of Chemistry, Stanford University, 333 Campus Dr., Stanford, California 94305, United States.
T Aaron BedellDepartment of Chemistry, Stanford University, 333 Campus Dr., Stanford, California 94305, United States.
J Du BoisDepartment of Chemistry, Stanford University, 333 Campus Dr., Stanford, California 94305, United States.ORCID 0000-0001-7847-1548
Stanford University · US

Funding

Guanidinium Toxins as Molecular Probes for NaV StudyR01GM117263 · NIGMS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2016 to 2024
$3.5M
Synthesis of New Bis-Guanidinium Toxins and Investigation of their Voltage-Gated Sodium Ion Channel AffinityF32GM122179 · NIGMS · STANFORD UNIVERSITY · PI BEDELL, THOMAS AARON · 2017 to 2019
$179k
NIGMS NIH HHS F32 GM122179NIGMS NIH HHS R01 GM117263
6 · The paper itself

Abstract

Saxitoxin (STX) is the archetype of a large family (>50) of architecturally distinct, bisguanidinium natural products. Among this collection of isolates, two members, 11-saxitoxinethanoic acid (11-SEA) and zetekitoxin AB (ZTX), are unique, bearing carbon substitution at C11. A desire to efficiently access these compounds has motivated the development of new tactical approaches to a late-stage C11-ketone intermediate

Indexed as

Biological ProductsSaxitoxinOxidation-Reduction11-saxitoxinethanoic acidBiological ProductsSaxitoxin

Identifiers

PMID34874731
PMCPMC8857915
OpenAlexW4200596142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.