Evidence map›Paper›PMID 34874605›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Impact of COVID-19 on the Onset and Progression of Alzheimer's Disease and Related Dementias: A Roadmap for Future Research.

Marcia N Gordon, Michael T Heneka, Lydia M Le Page, Christian Limberger, David Morgan, Andrea J Tenner, Niccolò Terrando, Auriel A Willette, Sara A Willette

Open access · hybridAbstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Article
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  10. Neurological, psychological, psychosocial complications of long-COVID and their management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  11. Article
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  13. Article
  14. Review
  15. Review
  16. Article
  17. Frontiers in neuroscience · 2024
    Review
  18. Infectious Diseases.Advances in neurobiology · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Marcia N GordonDept of Translational Neuroscience, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.
Michael T HenekaDept. of Neurodegenerative Disease and Geriatric Psychiatry/Neurology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53127 Bonn, Germany.
Lydia M Le PageDepartments of Physical Therapy and Rehabilitation Science, and Radiology and Biomedical Imaging, University of California, San Francisco, USA.
Christian LimbergerGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
David MorganDept of Translational Neuroscience, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.ORCID 0000-0003-1224-7476
Andrea J TennerMolecular Biology and Biochemistry, Neurobiology and Behavior and Pathology and Laboratory Medicine, University of California, Irvine, USA.
Niccolò TerrandoDepartment of Anesthesiology, Cell Biology, and Immunology, Duke University Medical Center, Durham, NC, 27710, USA.
Auriel A WilletteFood Science and Human Nutrition, Iowa State University, Ames, IA, USA.
Sara A WilletteIAC Tracker Inc., Ames, IA, USA.
Orthopaedic Associates of Michigan · USAmes National Laboratory · USDuke University · USIowa State University · USUniversidade Federal do Rio Grande do Sul · BRUniversity of Bonn · DEUniversity of California, Irvine · USUniversity of California, San Francisco · US

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Supplement to Cognitive training to reduce incidence of cognitive impairment in older adultsR01AG070349 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI Jennifer Lee O'Brien · 2021 to 2026
$50.5M
Neurovascular dysfunction in delirium superimposed on dementiaR01AG057525 · NIA · DUKE UNIVERSITY · PI Niccolo Terrando · 2017 to 2026
$6.7M
Immunovascular interactions in postoperative delirium superimposed on dementia (DSD).RF1AG079138 · NIA · DUKE UNIVERSITY · PI GELBARD, HARRIS A, TERRANDO, NICCOLO · 2022 to 2025
$3.6M
Understand and probing disrupted glucose metabolism in Alzheimer's diseaseRF1AG064170 · NIA · J. DAVID GLADSTONE INSTITUTES · PI CHAUMEIL, MYRIAM MARIANNE, NAKAMURA, KEN · 2019 to 2019
$3.6M
Influence of systemic immune inflammation upon the tauopathy phenotype in mouse modelsR01AG051500 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI MORGAN, DAVID · 2016 to 2020
$3.5M
Functional integrated human-on-a-chip systems for Alzheimer's researchR44AG058330 · NIA · HESPEROS, LLC · PI HICKMAN, JAMES J, MORGAN, DAVID · 2017 to 2020
$3.5M
Geroscience approaches to mitigate tauopathy in aged mouse brainR01AG062217 · NIA · MICHIGAN STATE UNIVERSITY · PI GORDON, MARCIA N · 2018 to 2022
$3.0M
Defining the Mechanistic Link between C5aR1 signaling and cognitive loss in Alzheimer's diseasesR01AG060148 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MORTAZAVI, SEYED ALI, TENNER, ANDREA JOAN · 2018 to 2021
$2.6M
Resolving orofacial neuropathic pain evoked by compression of a trigeminal nerve branch using rationally integrated complementary approachesP01AT009968 · NCCIH · DUKE UNIVERSITY · PI MATHEW, JOSEPH P · 2020 to 2020
$1.7M
Insulin Resistance, Biomarkers of Brain Function, and Intermittent Calorie RestrictionR00AG047282 · NIA · IOWA STATE UNIVERSITY · PI WILLETTE, AURIEL · 2016 to 2021
$730k
Bioelectronic rescue of cognitive impairment after surgeryR21AG055877 · NIA · DUKE UNIVERSITY · PI TERRANDO, NICCOLO · 2018 to 2019
$436k
NCCIH NIH HHS P01 AT009968NIA NIH HHS R00 AG047282NIA NIH HHS R01 AG051500NIA NIH HHS R01 AG057525NIA NIH HHS R01 AG060148NIA NIH HHS R01 AG062217NIA NIH HHS R01 AG070349NIA NIH HHS R03 AG064260NIA NIH HHS R21 AG055877NIA NIH HHS R44 AG058330NIA NIH HHS RF1 AG064170NIA NIH HHS RF1 AG079138NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

COVID-19 causes lasting neurological symptoms in some survivors. Like other infections, COVID-19 may increase risk of cognitive impairment. This perspective highlights four knowledge gaps about COVID-19 that need to be filled to avoid this possible health issue. The first is the need to identify the COVID-19 symptoms, genetic polymorphisms and treatment decisions associated with risk of cognitive impairment. The second is the absence of model systems in which to test hypotheses relating infection to cognition. The third is the need for consortia for studying both existing and new longitudinal cohorts in which to monitor long term consequences of COVID-19 infection. A final knowledge gap discussed is the impact of the isolation and lack of social services brought about by quarantine/lockdowns on people living with dementia and their caregivers. Research into these areas may lead to interventions that reduce the overall risk of cognitive decline for COVID-19 survivors.

Indexed as

Alzheimer DiseaseCognitive DysfunctionCOVID-19CaregiversCommunicable Disease ControlHumansAlzheimer's risk factorcaregiver burdenCOVID-19deleriumlongitudinal cohortSARS-CoV-2systemic inflammation

Identifiers

PMID34874605
PMCPMC9011667
OpenAlexW4200532204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.