Evidence map›Paper›PMID 34874597›Full record

ArticleChembiochem : a European journal of chemical biology2022

Quantitative Standards of 4-O-Acetyl- and 9-O-Acetyl-N-Acetylneuraminic Acid for the Analysis of Plasma and Serum.

Jack Cheeseman, Concepcion Badia, Rebecca I Thomson, Gunter Kuhnle, Richard A Gardner, Daniel I R Spencer, Helen M I Osborn

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Simultaneous ManNAc and Neu5Ac Quantification in Human Sera by LC-MS/MS.International journal of molecular sciences · 2026
    Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jack CheesemanSchool of Pharmacy, University of Reading Whiteknights, Reading, RG6 6AD, UK.
Concepcion BadiaLudger Ltd., Culham Science Centre, Abingdon, OX14 3EB, UK.
Rebecca I ThomsonSchool of Pharmacy, University of Reading Whiteknights, Reading, RG6 6AD, UK.
Gunter KuhnleDepartment of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, RG6 6AH, UK.
Richard A GardnerLudger Ltd., Culham Science Centre, Abingdon, OX14 3EB, UK.
Daniel I R SpencerLudger Ltd., Culham Science Centre, Abingdon, OX14 3EB, UK.
Helen M I OsbornSchool of Pharmacy, University of Reading Whiteknights, Reading, RG6 6AD, UK.ORCID 0000-0002-0683-0457
University of Reading · GBCulham Science Centre · GB

Funding

Medical Research Council MR/P015786/1
6 · The paper itself

Abstract

N-Acetylneuraminic acid (sialic acid, Neu5Ac) is one of a large, diverse family of nine-carbon monosaccharides that play roles in many biological functions such as immune response. Neu5Ac has previously been identified as a potential biomarker for the presence and pathogenesis of cardiovascular disease (CVD), diabetes and cancer. More recent research has highlighted acetylated sialic acid derivatives, specifically Neu5,9Ac

Indexed as

N-Acetylneuraminic AcidSialic AcidsMagnetic Resonance Spectroscopy9-O-acetyl-N-acetylneuraminic acidN-Acetylneuraminic AcidSialic Acidsacetylated sialic acidcarbohydratesDMB assayqNMR spectroscopyUHPLC

Identifiers

PMID34874597
PMCPMC9303589
OpenAlexW4200046285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.