Evidence map›Paper›PMID 34874478›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2022

A prospective randomized, double-blind study to evaluate the diagnostic efficacy of

Wenjia Zhu, Ru Jia, Qiao Yang, Yuejuan Cheng, Hong Zhao, Chunmei Bai, Jianming Xu, Shaobo Yao, Li Huo

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04318561 (A Prospective, Randomized, Double-blinded Study to Evaluate the Safety, Biodistribution, Dosimetry and Lesion Detection Ability of Gallium-68 Labeled LM3 for the Diagnostic Imaging of Metastatic, Well-differentiated Neuroendocrine Tumors Using PET/CT), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04318561 phase1 / phase2completednot on this map

A Prospective, Randomized, Double-blinded Study to Evaluate the Safety, Biodistribution, Dosimetry and Lesion Detection Ability of Gallium-68 Labeled LM3 for the Diagnostic Imaging of Metastatic, Well-differentiated Neuroendocrine Tumors Using PET/CT

TypeinterventionalSponsorPeking Union Medical College HospitalRan2019 to 2021Enrolled40ConditionsNeuroendocrine TumorsArmsGallium-68 NODAGA-LM3 PET/CT, Gallium-68 DOTA-LM3 PET/CT, Gallium-68 DOTATATE PET/CT
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Assessment of the diagnostic efficacy and clinical significance of [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  3. Evaluation of the safety, biodistribution, dosimetry of [European journal of nuclear medicine and molecular imaging · 2024
    Trial
  4. Development of dual SSTRSC medicinal chemistry · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Challenges and Opportunities in Radioligand Therapy.Journal of nuclear medicine technology · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Cytotoxicity Comparison ofMolecules (Basel, Switzerland) · 2025
    Article
  13. Synthesis and preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  14. Research process of PET tracers for neuroendocrine tumors diagnosis.American journal of nuclear medicine and molecular imaging · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. SSTR antagonist [European journal of nuclear medicine and molecular imaging · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wenjia ZhuDepartment of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Ru JiaDepartment of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, No. 8, East Avenue, Fengtai District, Beijing, China.
Qiao YangDepartment of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Yuejuan ChengDepartment of Oncology, Peking Union Medical College Hospital, Beijing, 100730, China.
Hong ZhaoDepartment of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Chunmei BaiDepartment of Oncology, Peking Union Medical College Hospital, Beijing, 100730, China.
Jianming XuDepartment of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, No. 8, East Avenue, Fengtai District, Beijing, China.
Shaobo YaoDepartment Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Li HuoDepartment of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. huoli@pumch.cn.ORCID http://orcid.org/0000-0003-1216-083X
Chinese Academy of Medical Sciences & Peking Union Medical College · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to evaluate the diagnostic efficacy of

methodsPatients were prospectively recruited and equally randomized into two arms: Arm A, patients would undergo a whole-body

resultsA total of 40 patients with well-differentiated NETs, 20 in each arm, were recruited in the study.

conclusionBoth

trial registrationClinicalTrials.gov identifier: NCT04318561.

Indexed as

Liver NeoplasmsNeuroendocrine TumorsOrganometallic CompoundsAcetatesDouble-Blind MethodGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansPositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesRadionuclide ImagingRadiopharmaceuticalsTissue Distribution1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidAcetatescopper dotatate CU-64Gallium RadioisotopesHeterocyclic Compounds, 1-RingOrganometallic CompoundsRadiopharmaceuticals68 Ga-DOTA-LM368 Ga-DOTATATE68 Ga-NODAGA-LM3Neuroendocrine tumorSomatostatin receptor antagonist

Identifiers

PMID34874478
OpenAlexW4200171984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.