Evidence map›Paper›PMID 34874401›Full record

ReviewAnesthesiology2022

Opioids and Public Health: The Prescription Opioid Ecosystem and Need for Improved Management.

Evan D Kharasch, J David Clark, Jerome M Adams

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05482919 (The Adolescent Surgery Experience), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05482919 completednot on this map

The Adolescent Surgery Experience: A Mixed Methods Analysis

TypeobservationalSponsorChildren's Hospital of PhiladelphiaRan2022 to 2023Enrolled501ConditionsPain, Postoperative, Pain, Pain, Acute, Pain, ChronicArmsBaseline Survey, Post Operative Surveys, Qualitative Interviews
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Observational
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Use of Muscle Relaxants for Acute Postoperative Pain: A Practical Review.Plastic and reconstructive surgery. Global open · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Opioid stewardship.BJA education · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Evan D KharaschDepartment of Anesthesiology, Duke University School of Medicine, Durham, North Carolina.
J David Clarkthe Anesthesiology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Jerome M AdamsPurdue University, West Lafayette, Indiana.
Duke University · USPurdue University West Lafayette · USVA Palo Alto Health Care System · US

Funding

OPTIMIZING OUTPATIENT ANESTHESIA: IMPROVING ANALGESIA AND REDUCING OPIOID MISADVENTURER01DA042985 · NIDA · WASHINGTON UNIVERSITY · PI KHARASCH, EVAN D. · 2017 to 2021
$2.2M
BLRD VA I01 BX000881NIDA NIH HHS R01 DA042985
6 · The paper itself

Abstract

While U.S. opioid prescribing has decreased 38% in the past decade, opioid deaths have increased 300%. This opioid paradox is poorly recognized. Current approaches to opioid management are not working, and new approaches are needed. This article reviews the outcomes and shortcomings of recent U.S. opioid policies and strategies that focus primarily or exclusively on reducing or eliminating opioid prescribing. It introduces concepts of a prescription opioid ecosystem and opioid pool, and it discusses how the pool can be influenced by supply-side, demand-side, and opioid returns factors. It illuminates pressing policy needs for an opioid ecosystem that enables proper opioid stewardship, identifies associated responsibilities, and emphasizes the necessity of making opioid returns as easy and common as opioid prescribing, in order to minimize the size of the opioid pool available for potential diversion, misuse, overdose, and death. Approaches are applicable to opioid prescribing in general, and to opioid prescribing after surgery.

Indexed as

Analgesics, OpioidDrug PrescriptionsHumansOpioid EpidemicOpioid-Related DisordersPostoperative PainPublic HealthAnalgesics, Opioid

Identifiers

PMID34874401
PMCPMC10715730
OpenAlexW4200352342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.