Evidence map›Paper›PMID 34874269›Full record

ArticleEpileptic disorders : international epilepsy journal with videotape2022

Electrical Wada for pre-surgical memory testing: a case report.

Erik Kaestner, Nigel P Pedersen, Ranling Hu, Armin Vosoughi, Abdulrahman Alwaki, Andres Rodriguez Ruiz, Ekaterina Staikova, Kelsey C Hewitt, Charles Epstein, Carrie R McDonald and 2 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Epileptic disorders : international epilepsy journal with videotape, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Erik KaestnerCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Nigel P PedersenDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA, Department of Biomedical Engineering, Georgia Tech, Atlanta, GA, USA.
Ranling HuDepartment of Radiology, Emory University, GA, USA.
Armin VosoughiDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Abdulrahman AlwakiDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Andres Rodriguez RuizDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Ekaterina StaikovaDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Kelsey C HewittDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Charles EpsteinDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Carrie R McDonaldCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA, Department of Psychiatry, University of California, San Diego, CA, USA, San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Robert E GrossDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA, Department of Neurosurgery, Emory University, Atlanta, GA, USA.
Daniel L DraneDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA, Department of Neurology, University of Washington, Seattle, WA, USA.
Emory University · USGeorgia Institute of Technology · USUniversity of California, San Diego · USUniversity of California System · US

Funding

National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe StructuresR01NS088748 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2014 to 2024
$6.4M
Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-makingR01NS124585 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2022 to 2025
$3.3M
Control of the Hippocampal Formation by the Supramammillary Hypothalamus - Anatomy, Physiology and in a Model of Medial Temporal Lobe EpilepsyK08NS105929 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PEDERSEN, NIGEL PAUL · 2018 to 2023
$963k
Multimodal imaging of memory reorganization in epilepsy from whole brain networks to local neuronal responses: Implications for surgical-decision-makingR56NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2020 to 2020
$467k
Sleep-Wake and Epilepsy Interactions in a Mouse Model of Temporal Lobe EpilepsR21NS122011 · NINDS · EMORY UNIVERSITY · PI PEDERSEN, NIGEL PAUL · 2021 to 2021
$430k
Development of a personalized neurostimulation protocol for memory mapping in epilepsyK01NS124831 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KAESTNER, ERIK JORDAN · 2022 to 2024
$339k
NIMH NIH HHS R01 MH118514NIMH NIH HHS T32 MH018399NINDS NIH HHS K01 NS124831NINDS NIH HHS K08 NS105929NINDS NIH HHS R01 NS065838NINDS NIH HHS R01 NS088748NINDS NIH HHS R01 NS124585NINDS NIH HHS R21 NS122011NINDS NIH HHS R56 NS065838
6 · The paper itself

Abstract

We report a case study of a surgical candidate, a 51-year-old woman with left temporal lobe epilepsy, who failed a left injection intracarotid amobarbital procedure (e.g., Wada test), scoring 0 of 8 items. This raised concerns for postoperative memory decline. However, the patient was uninterested in a neuromodulatory approach and wished to be reconsidered for surgery. A stereotactic laser amygdalohippocampotomy (SLAH) was considered, encouraging the need for an alternative test to evaluate risk of memory decline. We developed a novel approach to testing memory during stimulation of a depth electrode implanted in the hippocampus, i.e., an electric Wada. During multiple stimulation trials across a range of amplitudes, the patient scored up to 8 of 8 items, which suggested strong contralateral memory support. The surgical team proceeded with a radiofrequency ablation and a subsequent SLAH. The patient remains seizure-free at 12 months post SLAH with no evidence of verbal or visuospatial memory decline based on a post-surgical neuropsychological battery. We believe that this case study provides a proof of concept for the feasibility and possible utility of an electric version of the Wada procedure. Future studies are needed to develop an optimal paradigm and to validate this approach.

Indexed as

Epilepsy, Temporal LobeMemoryAmobarbitalFemaleFunctional LateralityHumansMemory DisordersMiddle AgedNeuropsychological TestsTemporal LobeAmobarbitalelectric Wadaintracarotid amobarbital procedureWada test

Identifiers

PMID34874269
PMCPMC9133096
OpenAlexW4200548640

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.