Evidence map›Paper›PMID 34874264›Full record

ReviewDeutsches Arzteblatt international2022

Pregnancy and Autoimmune Disease.

Waltraut Maria Merz, Rebecca Fischer-Betz, Kerstin Hellwig, Georg Lamprecht, Ulrich Gembruch

Open access · greenAbstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Sexual dimorphism in the liver.Nature reviews. Gastroenterology & hepatology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Waltraut Maria MerzDepartment of Obstetrics and Prenatal Medicine, Center for Obstetrics and Gynecology, University Hospital Bonn; Department of Rheumatology and Hiller, Forschungszentrum University Hospital Düsseldorf; Katholisches Klinikum Bochum, Neurology Clinic,Clinic of Ruhr-Universität Bochum; Department of Medicine II, Division of Gastroenterology and Endocrinology, University Medical Center Rostock; Department of Obstetrics and Prenatal Medicine, Center for Obstetrics and Gynecology, University Hospital Bonn.
Rebecca Fischer-Betz
Kerstin Hellwig
Georg Lamprecht
Ulrich Gembruch
University Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnancies in women with chronic disease are on the rise. This pertains to autoimmune diseases in particular since these tend to affect women of childbearing age. The interaction between pregnancy and autoimmune disease may increase the risk of maternal, fetal, and obstetric complications; additional care may be required.

methodsThis review is based on a selective literature search in PubMed (2015-2020).

resultsIn women with autoimmune diseases, the course of pregnancy is highly variable. Some autoimmune diseases tend to improve during pregnancy and do not to result in any serious obstetric complications. Others may worsen during pregnancy, with deterioration of the maternal condition as well as obstetric and perinatal complications. In systemic lupus erythematosus and myasthenia gravis, placental transfer of specific autoantibodies may cause fetal or neonatal disease.

conclusionThe care of pregnant women with chronic diseases requires collaboration between specialists of the pertinent levels of care. A stable course of disease before conception, close interdisciplinary care, and pregnancy-compatible medication contribute to a reduction in maternal and perinatal complications.

Indexed as

Autoimmune DiseasesLupus Erythematosus, SystemicPregnancy ComplicationsFemaleHumansInfant, NewbornPlacentaPregnancyPregnancy OutcomePrenatal Care

Identifiers

PMID34874264
PMCPMC9201458
OpenAlexW4200488709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.