Evidence map›Paper›PMID 34874199›Full record

ArticleRadiology2022

Abdominal US in Pediatric Inflammatory Multisystem Syndrome Associated with SARS-CoV-2 (PIMS-TS).

Riwa Meshaka, Fern C Whittam, Myriam Guessoum, Saigeet Eleti, Susan C Shelmerdine, Owen J Arthurs, Kieran McHugh, Melanie P Hiorns, Paul D Humphries, Alistair D Calder and 3 more

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In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Post-MIS-C cardiovascular outcomes: a systematic review.European journal of pediatrics · 2026
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Riwa MeshakaFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0001-7275-7297
Fern C WhittamFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0003-4604-7747
Myriam GuessoumFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).
Saigeet EletiFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0002-8235-0869
Susan C ShelmerdineFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0001-6642-9967
Owen J ArthursFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0003-1213-3516
Kieran McHughFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0001-6891-5213
Melanie P HiornsFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0002-3208-411X
Paul D HumphriesFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0002-6864-9100
Alistair D CalderFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0001-8335-299X
Marina J EastyFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0003-4922-3232
Edward P GaynorFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0003-0052-0543
Tom WatsonFrom the Department of Imaging, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, England (R.M., F.C.W., M.G., S.E., K.M., M.P.H., P.D.H., A.D.C., M.J.E., E.P.G., T.W.); NIHR Great Ormond Street Hospital Biomedical Research Centre, London, England (S.C.S., O.J.A.); and University College London Hospital, London, England (P.D.H.).ORCID 0000-0001-6079-3362
Great Ormond Street Hospital · GBUniversity College Hospital · GB

Funding

Medical Research Council MR/R002118/1
6 · The paper itself

Abstract

Background Children with pediatric inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children, present with abdominal pain among other nonspecific symptoms. Although initial imaging features of PIMS-TS have been reported, the duration of sonographic features remains unknown. Purpose To describe the abdominal US features of PIMS-TS at initial presentation and follow-up. Materials and Methods A retrospective review of children and young adults presenting with clinical features suspicious for PIMS-TS between April 2020 and June 2021 was carried out. US features were documented and reviewed at initial presentation and follow-up. Descriptive statistics were used and interobserver variability was calculated. Results Of 140 children and young adults presenting with suspected PIMS-TS, 120 had confirmed PIMS-TS (median age, 9 years; interquartile range, 7-12 years; 65 male patients) and 102 underwent abdominal US at presentation. PIMS-TS was present as a single abnormality in 109 of the 120 patients (91%) and abdominal symptoms were present in 104 of the 109 (95%). US examinations were abnormal in 86 of 102 patients (84%), with ascites being the most common abnormality in 65 (64%; 95% CI: 54, 73). Bowel wall thickening was present at US in 14 of the 102 patients (14%; 95% CI: 7, 20) and mesenteric inflammation was present in 16 (16%; 95% CI: 9, 23); all of these patients presented with abdominal symptoms. Among the patients with bowel wall thickening, the distal and terminal ileum were most involved (eight of 14 patients, 57%). Abdominal symptoms decreased to seven of 56 patients (13%) in those followed up at 6 months. Thirty-eight patients underwent follow-up US, and the presence of bowel inflammation had decreased to three of 27 patients (11%; 95% CI: -1, 23) in those followed up for less than 2 months and 0 of 17 (0%) in those followed up for more than 2 months. Conclusion Of 102 patients with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 who underwent US at presentation, 14 (14%) had abdominal US findings of bowel inflammation and 16 (16%) had mesenteric edema. All US abnormalities resolved after 2 months. © RSNA, 2022

Indexed as

COVID-19ChildHumansMaleRetrospective StudiesSARS-CoV-2Systemic Inflammatory Response Syndrome

Identifiers

PMID34874199
PMCPMC8961721
OpenAlexW4200094417

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.