Evidence map›Paper›PMID 34874183›Full record

ArticleScience translational medicine2022

Robust immune responses are observed after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2-experienced individuals.

Marie I Samanovic, Amber R Cornelius, Sophie L Gray-Gaillard, Joseph Richard Allen, Trishala Karmacharya, Jimmy P Wilson, Sara Wesley Hyman, Michael Tuen, Sergei B Koralov, Mark J Mulligan and 1 more

Abstract read
In one paragraph

Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Trial
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  9. Hybrid Immunity in a Mozambican Cohort After 1 or 2 Doses of the BBIBP-CorV Vaccine.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  10. Article
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  14. Review
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  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Marie I SamanovicNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-6987-2232
Amber R CorneliusNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Sophie L Gray-GaillardNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-4884-5956
Joseph Richard AllenNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-1119-1992
Trishala KarmacharyaNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-9141-8802
Jimmy P WilsonNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-6069-3855
Sara Wesley HymanNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Michael TuenNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Sergei B KoralovDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-4843-3791
Mark J MulliganNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-7262-9746
Ramin Sedaghat HeratiNYU Langone Vaccine Center, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-2613-4050

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI E. John Wherry · 2009 to 2026
$48.1M
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU) - DMID 21-0012UM1AI148574 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Angelica Cifuentes Kottkamp, Anoma Nellore · 2020 to 2026
$23.9M
ALABAMA/ZAMBIA HIV VACCINE CLINICAL TRIALS UNIT (HVTU)U01AI047996 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOEPFERT, PAUL A. · 2000 to 2006
$8.4M
Training a New Generation of VaccinologistsT32AI074492 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Benjamin A Lopman · 2009 to 2026
$6.4M
A systems immunology approach for predicting poor responses to Hepatitis B vaccinationR01AI158617 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HERATI, RAMIN · 2021 to 2025
$3.9M
Microbial triggers and molecular mechanisms of Th17 mediated airway inflammation-Resubmission-1R01HL125816 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2015 to 2019
$3.3M
Effects of aging on the T follicular helper response to influenza vaccineK08AI114852 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERATI, RAMIN · 2015 to 2019
$947k
Delineating The Differences Between Short-Lived And Long-Lived Plasma CellsR21AI137752 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2019 to 2020
$466k
Non-coding RNAs in B lymphocyte development and functionR21AI110830 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2014 to 2014
$170k
NCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL125816NIAID NIH HHS K08 AI114852NIAID NIH HHS R01 AI158617NIAID NIH HHS R21 AI110830NIAID NIH HHS R21 AI137752NIAID NIH HHS T32 AI074492NIAID NIH HHS U01 AI047996NIAID NIH HHS U19 AI082630NIAID NIH HHS UM1 AI148574
6 · The paper itself

Abstract

The use of coronavirus disease 2019 (COVID-19) vaccines will play the major role in helping to end the pandemic that has killed millions worldwide. COVID-19 vaccines have resulted in robust humoral responses and protective efficacy in human trials, but efficacy trials excluded individuals with a prior diagnosis of COVID-19. As a result, little is known about how immune responses induced by mRNA vaccines differ in individuals who recovered from COVID-19. Here, we evaluated longitudinal immune responses to two-dose BNT162b2 mRNA vaccination in 15 adults who had experienced COVID-19, compared to 21 adults who did not have prior COVID-19. Consistent with prior studies of mRNA vaccines, we observed robust cytotoxic CD8

Indexed as

BNT162 VaccineCOVID-19Antibodies, ViralCOVID-19 VaccinesHumansImmunity, HumoralmRNA VaccinesSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationVaccines, SyntheticAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesmRNA VaccinesSpike Glycoprotein, CoronavirusVaccines, Synthetic

Identifiers

PMID34874183
PMCPMC9248013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.