Evidence map›Paper›PMID 34874003›Full record

ArticleeLife2021

A conserved strategy for inducing appendage regeneration in moon jellyfish,

Michael J Abrams, Fayth Hui Tan, Yutian Li, Ty Basinger, Martin L Heithe, Anish Sarma, Iris T Lee, Zevin J Condiotte, Misha Raffiee, John O Dabiri and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
8.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Sleeping upside-down: Knockdown of a sleep-associated gene induces daytime sleep in the jellyfishProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Mammalian organ regeneration in spiny mice.Journal of muscle research and cell motility · 2023
    Review
  14. Article
  15. Toeing the line between regeneration and fibrosis.Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Michael J Abrams *Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Fayth Hui Tan *Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Yutian Li *Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID https://orcid.org/0000-0001-8151-3518
Ty BasingerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Martin L HeitheDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Anish SarmaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Iris T LeeDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Zevin J CondiotteDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Misha RaffieeDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
John O DabiriGraduate Aerospace Laboratories and Mechanical Engineering, California Institute of Technology, Pasadena, United States.
David A GoldDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Lea GoentoroDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID https://orcid.org/0000-0002-3904-0195
California Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Can limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the animal phylogeny. In Cnidaria, the frequency of appendage regeneration in the moon jellyfish

Indexed as

RegenerationAmputation, SurgicalAnimalsDrosophilaExtremitiesHindlimbMiceScyphozoaappendage regenerationD. melanogasterevolutionary biologyinsulinleucinelimb regenerationmoon jellyfishmouseregenerative medicinestem cellssucrose

Identifiers

PMID34874003
PMCPMC8782573
OpenAlexW4200194450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.