ArticlePhysiological reports2021
The impact of cardiac loading on a novel metric of left ventricular diastolic function in healthy middle-aged adults: Systolic-diastolic coupling.
Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Acute live firefighting effects on ventricular-arterial coupling and pulsatile afterload in middle-aged firefighters.Physiological reports · 2025Article
- Exercise echocardiography for improved assessment of diastolic filling dynamics.Experimental physiology · 2025Article
- Establishing a novel model to assess exercise capacity in chronic heart failure based on stress echocardiography.ESC heart failure · 2024Article
- Tipping the scale: Effects of physical activity and body composition on cardiac parameters in postmenopausal females.Physiological reports · 2024Article
- Impaired longitudinal systolic-diastolic coupling and cardiac response to exercise in patients with hypertrophic cardiomyopathy.Echocardiography (Mount Kisco, N.Y.) · 2024Article
- Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic-Diastolic Coupling in Middle-Aged Healthy Subjects.Journal of clinical medicine · 2023Article
- The impact of cardiac loading on a novel metric of left ventricular diastolic function in healthy middle-aged adults: Systolic-diastolic coupling.Physiological reports · 2021Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
aimsLeft ventricular (LV) restoring forces are primed by ventricular deformation during systole and contribute to cardiac relaxation and early diastolic suction. Systolic-diastolic coupling, the relationship between systolic contraction and diastolic recoil, is a novel marker of restoring forces, but the effect of left atrial pressure (LAP) is unknown. We tested preliminary methods of systolic-diastolic coupling comparing mitral annular velocities versus excursion distances and hypothesized a recoil/contraction distance ratio would remain unaffected across varying LAP, providing a surrogate for quantifying LV restoring forces. METHODS AND
resultsHealthy subjects (n = 61, age 52 ± 5 years) underwent manipulation of LAP with lower body negative pressure (LBNP) and rapid normal saline (NS) infusion. Pulmonary capillary wedge pressure (PCWP; pulmonary artery catheter) and tissue Doppler imaging of the mitral annulus were measured. Two models of systolic-diastolic coupling--early diastolic excursion (ED
conclusionsSystolic-diastolic coupling using mitral annular distance ratios to standardize early diastolic recoil to systolic contraction was not significantly impacted by LAP, in contrast to coupling ratios using velocities. The pressure invariance of annular distance coupling ratios suggests this metric quantifies the efficiency of LV restoring forces by isolating systolic contributions to early diastolic restoring forces independent from changes in LAP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.