ArticleDevelopmental science2022
Segregation and integration of the functional connectome in neurodevelopmentally 'at risk' children.
Article in Developmental science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Dynamic transient brain states in preschoolers mirror parental report of behavior and emotion regulation.Human brain mapping · 2024Article
- Article
- Testing the triple network model of psychopathology in a transdiagnostic neurodevelopmental cohort.NeuroImage. Clinical · 2023Article
- The Age of Reason: Functional Brain Network Development during Childhood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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Authors and funding
3 authors.
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Abstract
Functional connectivity within and between Intrinsic Connectivity Networks (ICNs) transforms over development and is thought to support high order cognitive functions. But how variable is this process, and does it diverge with altered cognitive development? We investigated age-related changes in integration and segregation within and between ICNs in neurodevelopmentally 'at-risk' children, identified by practitioners as experiencing cognitive difficulties in attention, learning, language, or memory. In our analysis we used performance on a battery of 10 cognitive tasks alongside resting-state functional magnetic resonance imaging in 175 at-risk children and 62 comparison children aged 5-16. We observed significant age-by-group interactions in functional connectivity between two network pairs. Integration between the ventral attention and visual networks and segregation of the limbic and fronto-parietal networks increased with age in our comparison sample, relative to at-risk children. Furthermore, functional connectivity between the ventral attention and visual networks in comparison children significantly mediated age-related improvements in executive function, compared to at-risk children. We conclude that integration between ICNs show divergent neurodevelopmental trends in the broad population of children experiencing cognitive difficulties, and that these differences in functional brain organisation may partly explain the pervasive cognitive difficulties within this group over childhood and adolescence.
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