Evidence map›Paper›PMID 34873718›Full record

ArticleJournal of medical virology2022

What is the true place of the SARS-CoV-2 rapid point-of-care antigen test in the hospital setting? Lessons learned from real life.

Steven Roger, Caroline Lefeuvre, Adeline Pivert, Alexandra Ducancelle, Dominique Savary, Élise Bouthry, Hélène Le Guillou-Guillemette

Open access · greenAbstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Article
  3. Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms.Chinese chemical letters = Zhongguo hua xue kuai bao · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Steven RogerDépartement de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.ORCID https://orcid.org/0000-0002-9220-2763
Caroline LefeuvreDépartement de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.ORCID http://orcid.org/0000-0003-4934-5926
Adeline PivertDépartement de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.ORCID https://orcid.org/0000-0002-8109-7881
Alexandra DucancelleDépartement de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.ORCID https://orcid.org/0000-0003-3173-8000
Dominique SavaryDépartement de Médecine des Urgences, CHU Angers, Angers, France.ORCID https://orcid.org/0000-0001-8480-5348
Élise BouthryDépartement de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.ORCID https://orcid.org/0000-0001-5083-8504
Hélène Le Guillou-GuillemetteDépartement de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.ORCID https://orcid.org/0000-0002-9340-7680
Centre Hospitalier Universitaire d'Angers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assist in the clinical management of patients and to support infection control, we tested the use of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) point-of-care antigen test (AgPOC) for unplanned hospitalization, coupled with a nucleic acid amplification test (NAAT) using specimens collected at the same time upon arrival. The aim of this study was to assess the performance of the AgPOC in this specific use compared to NAAT for SARS-CoV-2 diagnosis, in the context of the low prevalence of infection. For 5 months (between two peaks in France of the SARS-CoV-2 pandemic), all patients admitted who undertook the AgPOC/NAAT paired tests were included in the study. AgPOC performances were determined considering the clinical status and the delay of symptoms onset. NAAT and AgPOC results were available for 4425 subjects. AgPOC results showed a homogeneous specificity (>97%) but a low sensitivity at 45.8%. Considering the national guidelines, sensitivity dropped to 32.5% in cases of symptomatic patients with symptoms older than 5 days or more. This study shows the poor performance of AgPOC for entry screening of patients in hospitals. AgPOC may represent a useful tool in the hospital setting only if the use is restricted to patients with consistent symptoms less than 4 days old.

Indexed as

COVID-19 Serological TestingHospitalsPoint-of-Care TestingAdolescentAdultAgedAged, 80 and overAntigens, ViralCOVID-19COVID-19 Nucleic Acid TestingFemaleHumansMaleMiddle AgedSARS-CoV-2Sensitivity and SpecificityAntigens, Viralhospital screeningpoint-of-care testSARS-CoV-2SARS-CoV-2 antigen

Identifiers

PMID34873718
PMCPMC9015581
OpenAlexW4200320939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.