Evidence map›Paper›PMID 34873643›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

Multimodality imaging for diagnosis of subclinical hereditary transthyretin cardiac amyloidosis.

Talal Asif, Aviral Vij, Bartlomiej Radzik, Hudson Stern, Patricia Simples, Quraish Ghadiali, Saurabh Malhotra

Abstract readCase Reports
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Talal AsifDivision of Cardiology, Truman Medical Center, University of Missouri, Kansas City, USA.
Aviral VijDivision of Cardiology, Cook County Health, Chicago, USA.
Bartlomiej RadzikDivision of Pathology, Cook County Health, 1901 W. Harrison Street, Suite 3620, Chicago, 60612, USA.
Hudson SternDivision of Ophthalmology, Cook County Health, Chicago, USA.
Patricia SimplesDivision of Pathology, Cook County Health, 1901 W. Harrison Street, Suite 3620, Chicago, 60612, USA.
Quraish GhadialiDivision of Ophthalmology, Cook County Health, Chicago, USA.
Saurabh MalhotraDivision of Cardiology, Cook County Health, Chicago, USA. saurabh.malhotra@cookcountyhhs.org.
Cook County Health and Hospitals System · USRush University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a patient with worsening visual acuity and dense vitreal debris who was found to have vitreal transthyretin amyloid (ATTR) infiltration. Cardiac workup, performed to identify systemic amyloidosis, demonstrated focal myocardial amyloid infiltration on pyrophosphate (PYP) scintigraphy and cardiac magnetic resonance (CMR), resulting in a diagnosis of subclinical ATTR cardiac amyloidosis (ATTR-CA). Patient was identified as a carrier of p.S70R mutation which results in an aggressive ATTR phenotype. Patient is tolerating transthyretin silencer therapy well. Through this case, we discuss the role of a multimodality imaging approach for the diagnosis of subclinical ATTR-CA.

Indexed as

Amyloid Neuropathies, FamilialCardiomyopathiesHeartHumansPrealbuminPrealbuminCardiac magnetic resonanceHereditary transthyretin cardiac amyloidosisPyrophosphate scintigraphy

Identifiers

PMID34873643
OpenAlexW4200082251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.