Evidence map›Paper›PMID 34873637›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2022

PET imaging of reactive astrocytes in neurological disorders.

Yu Liu, Han Jiang, Xiyi Qin, Mei Tian, Hong Zhang

Open access · hybridAbstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Astrocyte Functional Heterogeneity in Multiple Sclerosis.Journal of clinical neurology (Seoul, Korea) · 2026
    Review
  2. Early astrocyte-targeted intervention guided byEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Review
  5. Quantification of monoamine oxidase B expression withEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  6. IND-Enabling Preclinical Studies of [Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2025
    Article
  7. Article
  8. Multi-tracer PET and MR imaging visualize distinct metabolic and inflammatory profiles in the white matter of NMOSD and MOGAD.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  9. PET imaging of TREM2 in amyloid-beta induced neuroinflammation.European journal of nuclear medicine and molecular imaging · 2025
    Article
  10. ISMRM Clinical Focus Meeting 2023: "Imaging the Fire in the Brain".Journal of magnetic resonance imaging : JMRI · 2025
    Article
  11. Astrocyte Reactivity Polygenic Risk Score May Predict Cognitive Decline in Alzheimer's Disease.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Collection on molecular imaging in neurodegeneration.European journal of nuclear medicine and molecular imaging · 2023
    Article
  18. Review
  19. Review
  20. [European journal of nuclear medicine and molecular imaging · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yu LiuDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Han JiangPET-CT Center, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Xiyi QinDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Mei TianDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. meitian@zju.edu.cn.
Hong ZhangDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. hzhang21@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNZhejiang University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reactive astrocytes manifest molecular, structural, and functional remodeling in injury, infection, or diseases of the CNS, which play a critical role in the pathological mechanism of neurological diseases. A growing need exists for dependable approach to better characterize the activation of astrocyte in vivo. As an advanced molecular imaging technology, positron emission tomography (PET) has the potential for visualizing biological activities at the cellular levels. In the review, we summarized the PET visualization strategies for reactive astrocytes and discussed the applications of astrocyte PET imaging in neurological diseases. Future studies are needed to pay more attention to the development of specific imaging agents for astrocytes and further improve our exploration of reactive astrocytes in various diseases.

Indexed as

Alzheimer DiseaseNervous System DiseasesAstrocytesHumansPositron-Emission TomographyTomography, X-Ray ComputedAlzheimer’s disease (AD)Amyotrophic lateral sclerosis (ALS)Monoamine oxidases-B (MAO-B)Multiple sclerosis (MS)Parkinson’s disease (PD)Positron emission tomography (PET)Reactive astrocytes

Identifiers

PMID34873637
PMCPMC8921128
OpenAlexW4200068631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.