ReviewEuropean archives of psychiatry and clinical neuroscience2022
Aerobic exercise in severe mental illness: requirements from the perspective of sports medicine.
Review in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07664540 (Targeting Autophagy in Depression), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Targeting Autophagy in Depression: Fasting, Exercise, Diet
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Meta-analysis of the effectiveness of exercise as an intervention for suicidal tendency in depressed patients.Frontiers in psychology · 2025Pooled it
- Effects of Physical Exercise on Executive Function in Adults with Depression: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Lifestyle interventions for people with a severe mental illness living in supported housing: A systematic review and meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Extended Long-Term Effects of Cognitive and Aerobic Training on Cognitive Function in Patients With Stress-Related Exhaustion Disorder: A 4.5-Year Follow-Up of a Randomized Controlled Trial.Stress and health : journal of the International Society for the Investigation of Stress · 2026Trial
- Effects of web-based adapted physical activity on hippocampal plasticity, cardiorespiratory fitness, symptoms, and cardiometabolic markers in patients with schizophrenia: a randomized, controlled study.European archives of psychiatry and clinical neuroscience · 2024Trial
- Step away from depression-results from a multicenter randomized clinical trial with a pedometer intervention during and after inpatient treatment of depression.European archives of psychiatry and clinical neuroscience · 2024Trial
- The influence of group physical activity on oxytocin, empathy, affect, and stress in individuals with schizophrenia spectrum disorders in a single-arm, pilot and exploratory study.Discover mental health · 2026Article
- Health Benefits of Cycling as a Form of Active Travel: A Pilot Empirical Study.International journal of environmental research and public health · 2026Article
- Determinants of physical activity and exercise in individuals with mental illness: results from a large cross-sectional online survey.BMJ open · 2025Article
- [Long-term courses in schizophrenia : A review of current results and developments].Der Nervenarzt · 2025Review
- Advising activity-knowledge, attitudes, beliefs, and behaviors regarding the recommendation of physical activity in clinical psychologists.European archives of psychiatry and clinical neuroscience · 2024Article
- Effects of Adapted Physical Activity on White Matter Integrity in Patients with Schizophrenia.Brain sciences · 2024Article
- The influence of marathon running on resting-state EEG activity: a longitudinal observational study.European journal of applied physiology · 2024Observational
- Introducing Braining-physical exercise as adjunctive therapy in psychiatric care: a retrospective cohort study of a new method.BMC psychiatry · 2023Article
- Depression, physical activity, and incident cardiovascular disease among American Indians: The strong heart family study.Psychiatry research communications · 2023Article
- Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management.International journal of bipolar disorders · 2023Article
- Physical activity levels associated with insomnia and depressive symptoms in middle-aged and elderly patients with chronic schizophrenia.Frontiers in psychiatry · 2022Article
- High-intensity interval training may reduce depressive symptoms in individuals with schizophrenia, putatively through improved VOFrontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Major depression, bipolar disorder, and schizophrenia are severe mental illnesses. Despite receiving psychopharmacological and psychosocial treatments, about half of patients develop a chronic course with residual cognitive and negative symptoms and have a high risk for cardiovascular disease and reduced life expectancy. Therefore, add-on innovative treatment approaches are needed to improve outcome. Aerobic exercise interventions have been shown to improve global functioning, cognition, and negative and depressive symptoms in these patients. The basic mechanism of these exercise-related changes has been reported to be improved brain plasticity, e.g., increased volume of disease-related brain regions such as the hippocampus. The optimal type, duration, and frequency of exercise have not yet been determined and need to be addressed in supervised physical exercise studies. Because of the low physical activity levels, lack of drive related to negative and depressive symptoms, and high prevalence of cardiovascular comorbidities in patients with severe mental illness, besides aiming to improve symptoms of mental illness, exercise interventions should also aim to increase cardiorespiratory fitness, which they should comprehensively assess by direct measurements of maximal oxygen uptake. Based on the recommendations for developing cardiorespiratory fitness by the American College of Sports Medicine, 150 min moderate-intensity training per week or vigorous-intensity exercise training for 75 min per week are appropriate. Most studies have had relatively short intervention periods, so future studies should focus on long-term adherence to exercise by implementing motivational strategies supported by telemedicine and by identifying and targeting typical barriers to exercise in this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.