Evidence map›Paper›PMID 34873483›Full record

ArticleAmerican journal of cancer research2021

Downregulation of Notch3 links TIMP3 inhibition to suppress aggressive phenotypes of pancreatic ductal adenocarcinoma.

Tai-Jan Chiu, Yi-Ju Chen, Jui Lan, Yen-Yang Chen, Yueh-Chiu Chen, Hsiao-Wu Lin, Hsin-Ting Tsai, Yu-Sheng Lin, Chang-Chun Hsiao, Chang-Han Chen

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Tai-Jan ChiuDivision of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Yi-Ju ChenDepartment of Anatomic Pathology, E-Da Hospital, I-Shou University Kaohsiung 84001, Taiwan.
Jui LanDepartment of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Yen-Yang ChenDivision of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Yueh-Chiu ChenDivision of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Hsiao-Wu LinDivision of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.
Hsin-Ting TsaiInstitute of Medicine, Chung Shan Medical University Taichung 40201, Taiwan.
Yu-Sheng LinState Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Sun Yat-sen University Guangzhou 510060, China.
Chang-Chun HsiaoGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University Taoyuan 33302, Taiwan.
Chang-Han ChenInstitute of Medicine, Chung Shan Medical University Taichung 40201, Taiwan.
Kaohsiung Chang Gung Memorial Hospital · TWChang Gung University · TWChung Shan Medical University · TWChung Shan Medical University Hospital · TWI-Shou University · TWSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC), one of the most deadly digestive cancers, has a poor 5-year survival rate and is resistant to chemotherapeutic agents, such as gemcitabine. Notch3 plays an important role in cancer progression, and its expression facilitates chemoresistance in cancers. This study examined the clinical significance of Notch3 and explored the mechanisms through which it may affect disease progression in PDAC. We found Notch3 to be upregulated in PDAC patients in whom it correlated with lymph node stage and poor survival.

Indexed as

gemcitabinemotilityNotch3Pancreatic ductal adenocarcinomaTIMP3

Identifiers

PMID34873483
PMCPMC8640811
OpenAlexW4206856970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.