Evidence map›Paper›PMID 34873434›Full record

ArticleProceedings. IEEE International Symposium on Biomedical Imaging2020

TENSOR-BASED GRADING: A NOVEL PATCH-BASED GRADING APPROACH FOR THE ANALYSIS OF DEFORMATION FIELDS IN HUNTINGTON'S DISEASE.

Kilian Hett, Hans Johnson, Pierrick Coupé, Jane S Paulsen, Jeffrey D Long, Ipek Oguz

Abstract read
In one paragraph

Article in Proceedings. IEEE International Symposium on Biomedical Imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Patch-Based Abnormality Maps for Improved Deep Learning-Based Classification of Huntington's Disease.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kilian HettVanderbilt University, Dept. of Electrical Engineering and Computer Science, Nashville TN, USA.
Hans JohnsonUniversity of Iowa, Dept. of Electrical and Computer Engineering, Iowa City, IA, USA.
Pierrick CoupéCNRS, University of Bordeaux, Bordeaux INP, LABRI, UMR5800, PICTURA, France.
Jane S PaulsenUniversity of Iowa, Dept. of Neuroscience, Iowa City IA, USA.
Jeffrey D LongUniversity of Iowa, Dept. of Psychiatry, Iowa City IA, USA.
Ipek OguzVanderbilt University, Dept. of Electrical Engineering and Computer Science, Nashville TN, USA.

Funding

NEUROBIOLOGICAL PREDICTORS OF HUNTINGTON'S DISEASER01NS040068 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2001 to 2013
$48.5M
Preparing for preventive clinical trials in Huntington's diseaseU01NS105509 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PAULSEN, JANE S · 2020 to 2025
$2.5M
Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington diseaseU01NS103475 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PAULSEN, JANE S · 2020 to 2022
$1.7M
Early detection of Huntington's Disease: Longitudinal analysis of basal ganglia and cortical thicknessR01NS094456 · NINDS · VANDERBILT UNIVERSITY · PI OGUZ, IPEK · 2016 to 2019
$1.3M
Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington diseaseR01NS103475 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S, ZHANG, YING · 2017 to 2018
$1.2M
Preparing for preventive clinical trials in Huntington's diseaseR01NS105509 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2018 to 2018
$658k
NINDS NIH HHS R01 NS040068NINDS NIH HHS R01 NS094456NINDS NIH HHS R01 NS103475NINDS NIH HHS R01 NS105509NINDS NIH HHS U01 NS103475NINDS NIH HHS U01 NS105509
6 · The paper itself

Abstract

The improvements in magnetic resonance imaging have led to the development of numerous techniques to better detect structural alterations caused by neurodegenerative diseases. Among these, the patch-based grading framework has been proposed to model local patterns of anatomical changes. This approach is attractive because of its low computational cost and its competitive performance. Other studies have proposed to analyze the deformations of brain structures using tensor-based morphometry, which is a highly interpretable approach. In this work, we propose to combine the advantages of these two approaches by extending the patch-based grading framework with a new tensor-based grading method that enables us to model patterns of local deformation using a log-Euclidean metric. We evaluate our new method in a study of the putamen for the classification of patients with pre-manifest Huntington's disease and healthy controls. Our experiments show a substantial increase in classification accuracy (87.5 ± 0.5 vs. 81.3 ± 0.6) compared to the existing patch-based grading methods, and a good complement to putamen volume, which is a primary imaging-based marker for the study of Huntington's disease.

Indexed as

Huntington’s diseasePatch-based gradingtensor-based morphometry

Identifiers

PMID34873434
PMCPMC8643362

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.