Evidence map›Paper›PMID 34873433›Full record

ArticleOxidative medicine and cellular longevity2021

MicroRNA-133b Inhibition Restores EGFR Expression and Accelerates Diabetes-Impaired Wound Healing.

Haobo Zhong, Jin Qian, Zhihong Xiao, Yan Chen, Xiangchun He, Chunhan Sun, Zhiming Zhao

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Role of exosome-derived miRNAs in diabetic wound angiogenesis.Molecular and cellular biochemistry · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Haobo ZhongDepartment of Orthopaedics, Huizhou First Hospital, Huizhou 516000, China.
Jin QianDepartment of Internal Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, China.
Zhihong XiaoThe Second Affiliated Hospital, Department of Spinal Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Yan ChenDepartment of Hand Surgery, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID https://orcid.org/0000-0001-7291-9049
Xiangchun HeDepartment of Internal Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, China.
Chunhan SunDepartment of Orthopaedics, Huizhou First Hospital, Huizhou 516000, China.ORCID https://orcid.org/0000-0001-7732-436X
Zhiming ZhaoDepartment of Orthopedics, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, China.ORCID https://orcid.org/0000-0003-3131-2843
Hubei University of Medicine · CNHuizhou Central People's Hospital · CNUniversity of South China · CNWuhan Puai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) are caused by impairments in peripheral blood vessel angiogenesis and represent a great clinical challenge. Although various innovative techniques and drugs have been developed for treating DFUs, therapeutic outcomes remain unsatisfactory. Using the GEO database, we obtained transcriptomic microarray data for DFUs and control wounds and detected a significant downregulation of epidermal growth factor receptor (

Indexed as

AnimalsCase-Control StudiesCell ProliferationDiabetic FootErbB ReceptorsGlucoseHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMicroRNAsRNA, MessengerWound HealingEGFR protein, humanEGFR protein, mouseErbB ReceptorsGlucoseMicroRNAsMIRN133 microRNA, humanMirn133 microRNA, mouseRNA, Messenger

Identifiers

PMID34873433
PMCPMC8643265
OpenAlexW3215406586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.