ArticleEvidence-based complementary and alternative medicine : eCAM2021
Evaluation of Antidiarrheal Activity of 80% Methanolic Extract of the Leaves of
Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Bioactivity Assessment and In Silico Target Engagement ofFood science & nutrition · 2026Article
- Antidiarrheal activity of the 80% methanol extract and solvent fractions of the leaves of Thymus schimperi (Lamiaceae) in mice.Scientific reports · 2026Article
- Evaluation of the Antidiarrheal Activity of 80% Methanolic Extract and Solvent Fractions of Calpurnia aurea (Ait.) Benth. (Fabaceae) Roots in Swiss Albino Mice.BioMed research international · 2026Article
- Article
- DecipheringAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Article
- Evaluation of Anti-Diarrheal Activities of the 80% Methanol Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Evaluation ofMetabolism open · 2022Article
- Evaluation of Antidiarrheal Activity of 80% Methanol Extract and Solvent Fractions of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiarrheal disease is a major cause of morbidity and mortality throughout the world, particularly in developing countries. Currently available drugs are linked with adverse effects, contraindications, and risk of resistance. Traditionally, the leaf concoction of
methodThe hydromethanolic extract was obtained by the cold maceration technique in 80% methanol. Phytochemical screening tests were done for secondary metabolites by using standard tests. The antidiarrheal activity of the test extract at the doses of 100, 200, and 400 mg/kg was evaluated by using castor oil-induced diarrheal, gastrointestinal transit, and enteropooling models in mice.
resultIn an acute toxicity study, there were no visible signs of toxicity and mortality following a single oral administration of 2000 mg/kg. Phytochemical screening tests revealed the presence of alkaloids, saponins, flavonoids, terpenoids, phenols, and tannins. The hydromethanolic extract significantly prolonged the onset of diarrhea and reduced the weight of wet and total feces at 100 (
conclusionThe study demonstrated that the test extract showed promising antidiarrheal activity. Hence, this study supports its antidiarrheal use in Ethiopian folklore medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.