Evidence map›Paper›PMID 34873208›Full record

ArticleScientific reports2021

Pilot imaging study of o-BMVC foci for discrimination of indeterminate cytology in diagnosing fine-needle aspiration of thyroid nodules.

Ting-Yuan Tseng, Shyang-Rong Shih, Cheng-Ping Wang, Shang-Jyun Lin, I-Shiow Jan, Chiung-Lin Wang, Shin-Ya Liu, Cheng-Chung Chang, Pei-Jen Lou, Ta-Chau Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ting-Yuan TsengInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106, Taiwan.
Shyang-Rong ShihDivision of Metabolism and Endocrinology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, 100, Taiwan.
Cheng-Ping WangDepartment of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, 100, Taiwan.
Shang-Jyun LinInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106, Taiwan.
I-Shiow JanDepartment of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, 100, Taiwan.
Chiung-Lin WangInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106, Taiwan.
Shin-Ya LiuInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106, Taiwan.
Cheng-Chung ChangGraduate Institute of Biomedical Engineering, National Chung-Hsing University, Taichung, 402, Taiwan.
Pei-Jen LouDepartment of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, 100, Taiwan. pjlou@ntu.edu.tw.
Ta-Chau ChangInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 106, Taiwan. tcchang@po.iams.sinica.edu.tw.
Institute of Atomic and Molecular Sciences, Academia Sinica · TWNational Taiwan University Hospital · TWNational Chung Hsing University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescence lifetime imaging microscopy of a fluorescence probe, 3,6-bis(1-methyl-2-vinylpyridinium) carbazole diiodide (o-BMVC), provides an objective method for preoperative diagnosis of fine-needle aspiration (FNA) of thyroid nodules. The key of this o-BMVC test of FNA smears is the measurement of the digital number of o-BMVC foci in the nucleus. Thus, there are three categories classified in the o-BMVC test, which are nondiagnostic for unsatisfactory samples, benign for less numbers of o-BMVC foci, and malignant for more numbers of o-BMVC foci. The discrimination of indeterminate (including atypia, follicular neoplasm, suspicious) cytology into benign or malignant cases can reduce diagnostic uncertainty and benefit clinical decision making. This pilot study strongly suggests that the o-BMVC test is an invaluable method for diagnosing FNA samples. Particularly, the combination of FNA cytology and the o-BMVC test holds great promise to improve the efficacy of diagnosis and reduce the healthcare costs.

Indexed as

AdolescentAdultAgedAged, 80 and overBiopsy, Fine-NeedleCarbazolesCytodiagnosisFemaleFluorescent DyesHumansMaleMicroscopy, FluorescenceMiddle AgedPilot ProjectsPyridinium CompoundsThyroid GlandcarbazoleCarbazolesFluorescent DyesPyridinium Compounds

Identifiers

PMID34873208
PMCPMC8648827
OpenAlexW4200358264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.