ArticleNature communications2021
Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome.
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In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies.Annals of clinical and translational neurology · 2026Observational
- Engineered dCas12f1-SAM enables robust transcriptional activation and gain-of-function screening in primary human cells.Nature communications · 2026Article
- CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A scoping review of statistical methods to investigate colocalization between genetic associations and microRNA expression in osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Differential impact of environmental factors on systemic and localized autoimmunity.Frontiers in immunology · 2023Review
- Omics approaches to understanding the efficacy and safety of disease-modifying treatments in multiple sclerosis.Frontiers in genetics · 2023Review
- Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action.Inflammopharmacology · 2022Review
- Epigenetic control of ataxin-1 in multiple sclerosis.Annals of clinical and translational neurology · 2022Article
- Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation.International journal of molecular sciences · 2022Article
- RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.PLoS biology · 2022Article
- Differential DNA methylation associated with multiple sclerosis and disease modifying treatments in an underrepresented minority population.Frontiers in genetics · 2022Article
- Association ofInternational journal of endocrinology · 2022Article
- Specific hypomethylation programs underpin B cell activation in early multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genomic Multiple Sclerosis Risk Variants Modulate the Expression of theFrontiers in immunology · 2021Article
- Exploring the complexities of epigenetics in multiple sclerosis: A study involving meta-analysis of DNA methylation profiles, epigenetic drift, and rare epivariations.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
19 authors.
Tina RoostaeiCenter for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's disease and the Aging brain, Columbia University Irving Medical Center, New York, NY, USA.
Hans-Ulrich KleinCenter for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's disease and the Aging brain, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6382-9428
Yiyi MaCenter for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's disease and the Aging brain, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3609-8877
Daniel FelskyKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1831-9848
Pia KivisäkkAlzheimer's Clinical and Translational Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Sarah M ConnorCenter for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's disease and the Aging brain, Columbia University Irving Medical Center, New York, NY, USA.
Alexandra KroshilinaCenter for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's disease and the Aging brain, Columbia University Irving Medical Center, New York, NY, USA.
Christina YungCenter for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's disease and the Aging brain, Columbia University Irving Medical Center, New York, NY, USA.
Belinda J KaskowAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xiaorong ShaoGenetic Epidemiology and Genomics Laboratory, University of California, Berkeley, CA, USA.
Brooke RheadGenetic Epidemiology and Genomics Laboratory, University of California, Berkeley, CA, USA.
José M OrdovásJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7581-5680
Devin M AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0003-2219-657X
Jia LiuAdvanced Science Research Center at the Graduate Center, Neuroscience Initiative, City University of New York, New York, NY, USA.ORCID http://orcid.org/0000-0001-6274-2710
Nikolaos PatsopoulosAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lisa F BarcellosGenetic Epidemiology and Genomics Laboratory, University of California, Berkeley, CA, USA.
Howard L WeinerAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0203-9681
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's disease and the Aging brain, Columbia University Irving Medical Center, New York, NY, USA. pld2115@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-8057-2505
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying the effects of genetic variation on the epigenome in disease-relevant cell types can help advance our understanding of the first molecular contributions of genetic susceptibility to disease onset. Here, we establish a genome-wide map of DNA methylation quantitative trait loci in CD4
Indexed as
DNA MethylationAdolescentAdultCD4-Positive T-LymphocytesCells, CulturedEpigenomeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHaplotypesHumansMaleMiddle AgedMultiple SclerosisPolymorphism, Single Nucleotide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.