Evidence map›Paper›PMID 34873150›Full record

ArticleTranslational psychiatry2021

Moderators of inflammation-related depression: a prospective study of breast cancer survivors.

Andrew W Manigault, Patricia A Ganz, Michael R Irwin, Steve W Cole, Kate R Kuhlman, Julienne E Bower

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Remote blood collection among cancer patients and age- and sex-matched controls for biomarker and genetic analyses using the PROFILES registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Towards a multidimensional model of inflamed depression.Brain, behavior, & immunity - health · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrew W ManigaultDepartment of Psychology, UCLA, Los Angeles, CA, USA. andrewmanigaultw@gmail.com.ORCID http://orcid.org/0000-0003-4197-1295
Patricia A GanzDavid Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Michael R IrwinDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
Steve W ColeDavid Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Kate R KuhlmanCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Julienne E BowerDepartment of Psychology, UCLA, Los Angeles, CA, USA.
University of California, Los Angeles · USNeurobehavioral Systems · USUniversity of California, Irvine · US

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Behavioral and inflammatory responses to stress: Implications for depression in youth exposed to adversityK08MH112773 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUHLMAN, KATE RYAN · 2017 to 2021
$862k
NIMH NIH HHS K08 MH112773NIMH NIH HHS T32 MH015750U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA10950
6 · The paper itself

Abstract

Inflammation has been shown to predict depression, but sensitivity to inflammation varies across individuals. Experimental studies administering potent pro-inflammatory agents have begun to characterize this sensitivity. However, risk factors for inflammation-associated depression in naturalistic contexts have not been determined. The present study examined key psychological and behavioral risk factors (state anxiety, perceived stress, negative affect, disturbed sleep, and childhood adversity) as potential moderators of the relationship between inflammation and depressive symptoms in a prospective longitudinal study of breast cancer survivors. Women with early stage breast cancer were recruited after completing primary cancer treatment (n

Indexed as

Breast NeoplasmsCancer SurvivorsDepressionFemaleHumansInflammationLongitudinal StudiesProspective Studies

Identifiers

PMID34873150
PMCPMC8648787
OpenAlexW4200244638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.